Table 1.

Characteristics of adenoma case and control subjects

MenWomen
Case (n = 498)Control (n = 453)PCase (n = 240)Controls (n = 244)P
Agea, y61.3 (5.9)60.0 (5.7)0.00159.8 (6.6)59.6 (6.4)0.68
BMI, kg/m224.0 (2.6)23.4 (2.7)0.00122.6 (3.2)22.2 (2.8)0.15
Alcohol intake, g/wk228.9 (231.8)185.2 (202.9)0.00239.1 (89.1)44.4 (104.2)0.54
Physical activity, METS-h/d36.1 (8.9)35.7 (6.6)0.4638.1 (9.7)37.9 (9.2)0.83
Smoking history, n (%)<0.0010.11
 Never smoker139 (27.9)149 (32.9)192 (80.0)213 (87.3)
 Past smoker231 (46.4)242 (53.4)30 (12.5)23 (9.4)
 Current, ≤20 cig/d73 (14.7)39 (8.6)17 (7.1)7 (2.9)
 Current, >20 cig/d55 (11.0)23 (5.1)1 (0.4)1 (0.4)
Parental colorectal cancer, n (%)44 (8.8)35 (7.7)0.5633 (13.8)18 (7.4)0.02
NSAID use, n (%)20 (4.0)38 (8.4)0.00612 (5.0)15 (6.1)0.58
Menarche age, y13.3 (1.5)13.2 (1.4)0.97
Postmenopause, n (%)216 (90.0)218 (89.3)0.81
Hormone use, n (%)23 (9.6)29 (11.9)0.41
Dietary intake, median (IQR)
 Total energy, kcal/d1,930 (1,643–2,350)1,924 (1,605–2,269)0.141,917 (1,550–2,261)1,792 (1,518–2,122)0.03
 Fiber, g/d11.1 (8.5–14.1)11.5 (8.9–15.0)0.0615.3 (12.3–18.2)15.6 (12.7–18.2)0.45
 Folate, μg/d361(271–444)356 (283–463)0.34447 (356–555)463 (374–567)0.15
 Isoflavone, mg/d33.2 (20.3–52.9)35.1 (21.9–56.2)0.1041.2 (24.1–63.5)44.9 (30.4–63.0)0.07
 Total meat, g/d43.7 (26.3–65.9)43.6 (27.6–66.8)0.9848.9 (28.8–74.9)40.4 (24.4–64.3)0.02
 Red meat, g/d27.9 (14.8–43.2)27.0 (15.7–44.3)0.8928.5 (15.8–46.7)24.4 (14.8–39.9)0.07
 Processed meat, g/d3.0 (0.6–8.3)3.6 (0.8–7.8)0.534.8 (1.9–9.9)3.7 (0.8–9.0)0.04
 Poultry, g/d7.9 (3.5–14.5)9.1 (3.5–15.8)0.529.3 (3.1–17.8)8.0 (1.3–15.8)0.05
 Fish, g/d61.5 (39.7–88.1)58.4 (39.8–82.8)0.6268.5 (48.0–91.5)72.6 (47.4–98.7)0.56
 PhIP, ng/d17.7 (11.7–26.5)18.3 (10.9–27.1)0.6820.2 (13.7–30.4)17.8 (12.3–26.0)0.03
 MeIQx, ng/d4.0 (2.7–5.7)4.0 (2.5–6.0)0.674.5 (3.0–6.7)4.2 (2.7–5.8)0.04
 MeIQ, ng/d3.4 (2.4–5.1)3.6 (2.3–5.1)0.903.9 (2.8–6.0)3.5 (2.2–5.2)0.005
 Total HCA, ng/d28.9 (19.4–44.4)30.0 (17.8–44.5)0.7133.0 (21.9–48.5)28.0 (18.2–42.7)0.02

Abbreviation: IQR, interquartile range.

  • aValues are means (SD) where not mentioned.