Table 4.

Determinants of cotinine and nicotine glucuronidation

ModelR2NPercentage variation explained
A. Cotinine glucuronidation
Nicotine equivalents0.00012,239NA
 +Sex0.00052,2390.04
 +Age0.00372,2390.32
 +Race0.08872,2398.50
 +Principal components 1–100.11142,2392.27Base
Base model: Cotinine glucuronidation = nicotine equivalents + sex + age + race + principal components 1–10
Data
 Base model + 15 SNPs from stepwise0.44332,23933.19Compared with base
 Base model + weighted GS with 15 SNPs from stepwisea0.42462,23931.32Compared with base
B. Nicotine glucuronidation
Nicotine equivalents0.00682,239NA
 +Sex0.00692,2390.01
 +Age0.01212,2390.52
 +Race0.04472,2393.26
 +Principal components 1–100.05132,2390.66Base
Base model: Nicotine glucuronidation = nicotine equivalents + sex + age + race + principal components 1–10
Data
 Base model + 2 SNPs from stepwise (rs116224959 and rs4132568)0.14122,2398.99Compared with base
 Base model + CotGluc weighted GS with 15 SNPs from stepwise (from model in “A. Cotinine glucuronidation”)0.13652,2398.52Compared with base
  • aThe weighted GS was weighted with the betas from the overall GWAS results.