Table 2.

Algorithm performance

Patient groupNumber sampledNumber in THINPPV for bladder cancer, 95% CIPPV for muscle-invasive bladder cancer, 95% CI
All patients19418, 97399.5 (97.2–99.9)N/A
Patients without cystectomy9917,62699.0 (94.5–99.9)N/A
Patients with cystectomy95a1,347100.0 (96.2–100.0)70.1 (59.4–79.5)
 Cystectomy without metastases or death46485100.0 (92.3–100.0)61.0 (45.4–74.9)
 Cystectomy with metastases, alive1078100.0 (69.2–100.0)70.0 (34.7–93.3)
 Cystectomy with metastases, dead31784100.0 (88.8–100.0)83.9 (66.3–94.5)
 Weighted calculationb74.8 (62.6–87.4)
  • aEight patients were excluded due to incomplete records.

  • bPPV for muscle-invasive bladder cancer using the proportional representation of cystectomy subsets in the full THIN population [(0.61 × 485/1347) + (0.70 × 78/1347) + (0.839×784/1347)].