Table 2.

Main effects of child's, mother's, and father's folate pathway genotypes on risk of childhood ALL

Child genotypeMother genotypeFather genotype
N cases/controlsCase–control analysis (n = 392/535)Case–parent trios (n = 276)Case–control analysis (n = 391/501)Case–control analysis (n = 344/444)
PolymorphismGenotypeN cases/controlsaORb (95% CI)OR (95% CI)N cases/controlsaORb (95% CI)N cases/controlsaORc (95% CI)
MTHFR 677 C>TCC166/2441.00 (reference)1.00 (reference)176/2121.00 (reference)131/2041.00 (reference)
(rs1801133)CT181/2211.22 (0.92–1.63)1.10 (0.80–1.51)170/2280.90 (0.67–1.20)170/1881.41 (1.02–1.93)
TT43/601.23 (0.77–1.97)0.92 (0.54–1.56)43/521.15 (0.71–1.86)41/431.81 (1.06–3.07)
CT/TT224/2811.23 (0.94–1.62)1.08 (0.79–1.48)213/2800.94 (0.71–1.24)211/2311.48 (1.09–2.00)
MTHFR 1298 A>CAA195/2641.00 (reference)1.00 (reference)177/2281.00 (reference)159/2131.00 (reference)
(rs1801131)AC169/1921.04 (0.78–1.38)0.77 (0.57–1.05)178/2030.98 (0.73–1.31)156/1641.09 (0.80–1.49)
CC27/520.98 (0.54–1.79)0.49 (0.28–0.87)35/471.38 (0.79–2.42)25/441.06 (0.56–2.01)
AC/CC196/2441.02 (0.78–1.35)0.74 (0.55–1.01)213/2501.03 (0.77–1.37)181/2081.08 (0.80–1.47)
MTRR 66A>GAA88/1011.00 (reference)1.00 (reference)81/971.00 (reference)82/751.00 (reference)
(rs1801394)AG208/2330.84 (0.58–1.22)0.95 (0.66–1.38)195/2290.82 (0.56–1.21)160/2040.62 (0.41–0.93)
GG88/1740.60 (0.39–0.91)0.71 (0.44–1.16)105/1430.94 (0.61–1.44)88/1290.64 (0.40–1.03)
AG/GG296/4070.75 (0.53–1.06)0.92 (0.63–1.32)300/3720.87 (0.60–1.24)248/3330.62 (0.42–0.93)
MTR 2756 A>GAA251/3371.00 (reference)1.00 (reference)253/3021.00 (reference)219/2741.00 (reference)
(rs1805087)AG130/1581.00 (0.75–1.34)1.12 (0.79–1.58)118/1420.86 (0.64–1.17)106/1190.93 (0.67–1.29)
GG10/191.70 (0.52–5.58)0.47 (0.19–1.19)19/291.82 (0.73–4.56)12/191.93 (0.58–6.35)
AG/GG140/1771.03 (0.78–1.37)1.07 (0.76–1.52)137/1710.92 (0.69–1.23)118/1380.98 (0.71–1.34)
MTR 5049 C>ACC155/1991.00 (reference)1.00 (reference)161/1811.00 (reference)131/1601.00 (reference)
(rs285523)CA181/2290.98 (0.72–1.32)1.12 (0.80–1.57)172/2120.92 (0.68–1.25)159/1821.06 (0.76–1.49)
AA55/831.04 (0.67–1.61)1.27 (0.76–2.13)56/711.09 (0.69–1.70)49/641.14 (0.70–1.86)
CA/AA236/3121.01 (0.76–1.33)1.13 (0.82–1.58)228/2830.96 (0.72–1.28)208/2461.08 (0.79–1.49)
CBS 2199 T>CTT118/1471.00 (reference)1.00 (reference)110/1431.00 (reference)110/1231.00 (reference)
(rs706208)TC179/2530.82 (0.59–1.13)0.92 (0.65–1.29)188/2380.95 (0.68–1.32)166/2000.89 (0.62–1.27)
CC88/1051.23 (0.82–1.84)1.34 (0.84–2.15)85/851.47 (0.96–2.26)53/810.81 (0.50–1.31)
TC/CC267/3580.94 (0.69–1.28)0.96 (0.69–1.35)273/3231.08 (0.79–1.47)219/2810.88 (0.63–1.24)
CBS 844 Ins 68dWTWT450/3291.00 (reference)1.00 (reference)336/4091.00 (reference)288/3601.00 (reference)
WTIns/InsIns55/690.79 (0.53–1.17)1.03 (0.62–1.72)49/710.67 (0.44–1.01)48/690.67 (0.44–1.01)
  • aNumbers are from raw data before correction imputation method applied, individual polymorphism Ns may vary from total due to typing fails.

  • bORs adjusted for matching variables (child's age, sex, and state of residence), mother's age group, parental education, birth order, and ethnicity.

  • cORs adjusted for matching variables (child's age, sex, and state of residence), father's age group, parental education, birth order, and ethnicity.

  • dN for homozygous mutants insufficient to produce separate OR.