Table 2.

Height and overall adiposity associations with ERPR breast cancer in premenopausal women, by ethnicity

AllHispanicsNHWs
ERPR casesControlsERPRcasesControlsERPR casesControls
(n = 247)(n = 1,418)(n = 142)(n = 765)(n = 105)(n = 653)
nnORa (95% CI)nnORa (95% CI)nnORb (95% CI)
Current height (cm)c,d
 T1: <157.1704681.0593941.011741.0
 T2: 157.1–163.2754661.07 (0.75–1.55)452521.11 (0.72–1.70)302140.93 (0.44–1.97)
 T3: >163.21024821.50 (1.03–2.19)381171.91 (1.19–3.07)643651.13 (0.57–2.26)
Ptrend = 0.03Ptrend = 0.01Ptrend = 0.51
Current height (cm)d,e
 Tertile 1332521.0342151.0
 Tertile 2442521.20 (0.73–1.98)292160.85 (0.50–1.45)
 Tertile 3652591.64 (1.03–2.63)422211.13 (0.69–1.85)
Ptrend = 0.01Ptrend = 0.51
 Per 5 cm1.12 (1.01–1.25)1.22 (1.05–1.41)1.03 (0.87–1.21)
Young-adult BMI (kg/m2)c,f
 T1: <20.6884461.0461571.0422891.0
 T2: 20.6–23.1844460.90 (0.64–1.26)512300.76 (0.48–1.20)332161.06 (0.65–1.75)
 T3: >23.1594590.63 (0.43–0.93)383390.41 (0.25–0.68)211201.23 (0.69–2.21)
Ptrend = 0.02Ptrend < 0.01Ptrend = 0.50
Young-adult BMI (kg/m2)f,g
 Tertile 1642391.0282061.0
 Tertile 2412400.67 (0.43–1.05)322061.16 (0.67–2.01)
 Tertile 3302470.50 (0.31–0.81)362121.26 (0.74–2.17)
Ptrend < 0.01Ptrend = 0.50
 Per 5 kg/m20.88 (0.72–1.08)0.73 (0.55–0.95)1.20 (0.88–1.64)
Current BMI (kg/m2)h
 <25.01065761.0532121.0533641.0
 25.0–29.9764460.99 (0.71–1.38)482860.77 (0.50–1.20)281601.34 (0.81–2.22)
 ≥30.0653940.98 (0.69–1.40)412650.71 (0.45–1.12)241291.45 (0.85–2.48)
Ptrend = 0.93Ptrend = 0.15Ptrend = 0.14
 Per 5 kg/m20.98 (0.88–1.10)0.83 (0.71–0.98)1.16 (0.99–1.35)
Weight gain (kg)c,i
 T1: <8.2754141.0461831.0292311.0
 T2: 8.2–16.3633970.90 (0.63–1.30)362290.65 (0.40–1.06)271681.35 (0.76–2.38)
 T3: >16.3764171.05 (0.74–1.50)442500.73 (0.46–1.17)321671.68 (0.96–2.93)
Ptrend = 0.79Ptrend = 0.21Ptrend = 0.07
Weight gain (kg)i,j
 Tertile 1552331.0231941.0
 Tertile 2282040.60 (0.36–0.98)291731.52 (0.84–2.75)
 Tertile 3432250.86 (0.54–1.35)361981.71 (0.96–3.06)
Ptrend = 0.21Ptrend = 0.07
 Per 5 kg1.02 (0.95–1.09)0.96 (0.87–1.05)1.07 (0.98–1.17)
  • aORs and 95% CIs, adjusted for age (years, continuous), study (SFBCS, 4-CBCS), ethnicity/English language acculturation (low, moderate, high, and NHW), and average alcohol consumption in reference year (g/d; 0, 0.1–4.9, 5–9.9, 10–19.9, ≥20).

  • bAdjusted for all variables above except English language acculturation.

  • cBased on tertiles among all premenopausal controls.

  • dBased on measured height at interview (or self-reported adult height when measured height was not available).

  • eBased on ethnicity-specific tertiles among premenopausal controls in each ethnic group. Tertile cut points by ethnicity are <154.0, 154.1–159.4, and >159.4 for Hispanics, and <161.8, 161.8–167.0, and >167.0 for NHWs.

  • fBased on self-reported averaged weight at age 15 and age 30 for 4-CBCS cases and controls, self-reported weight in the 20s for SFBCS cases and controls (between ages 25–30 for cases diagnosed from April 1995 to April 1998 and matched controls and between ages 20–29 for cases diagnosed from May 1998 to April 2002 and matched controls), and measured height at interview (or self-reported adult height when measured height was not available).

  • gBased on ethnicity-specific tertiles among premenopausal controls in each ethnic group. Tertile cut points by ethnicity are <21.5, 21.5–24.3, and >24.3 for Hispanics, and <20.0, 20.0–21.8, and >21.8 for NHWs.

  • hBased on self-reported weight in reference year (or measured weight at interview when self-reported weight in reference year was not available) and measured height at interview (or self-reported adult height when measured height was not available).

  • iBased on self-reported weight in reference year (or measured weight at interview when self-reported weight was not available) minus self-reported young-adult weight; excludes 17 premenopausal ERPR cases and 125 premenopausal controls who lost weight.

  • jBased on ethnicity-specific tertiles among premenopausal controls in each ethnic group. Tertile cut points by ethnicity are <9.1, 9.1–17.3, and >17.3 for Hispanics, and <6.8, 6.8–14.7, and >14.7 for NHWs.