Table 4.

ORs for folate pathway genotypes stratified by maternal use of folic acid (≥300 μg) in the 3 months before pregnancy

N cases/controlsChild (354/495a)Mother (353/461a)
PolymorphismFolic acidGenotypen case/controlaORb (95% CI)n case/controlaORb (95% CI)
MTHFR 677 C>TNoneCC117/1441.0 (reference)127/1291.0 (reference)
CT115/1341.03 (0.72–1.50)104/1370.74 (0.51–1.08)
TT27/410.94 (0.52–1.71)28/331.02 (0.55–1.90)
CT/TT142/1751.03 (0.72–1.45)132/1700.80 (0.56–1.13)
≥300 μgCC32/801.0 (reference)32/631.0 (reference)
CT50/671.92 (1.07–3.43)48/751.26 (0.69–2.29)
TT11/191.63 (0.65–4.11)12/152.01 (0.77–5.24)
CT/TT61/861.85 (1.06–3.23)60/901.36 (0.77–2.41)
MTHFR 1298A>CNoneAA130/1641.0 (reference)119/1391.0 (reference)
AC111/1161.03 (0.71–1.49)114/1310.86 (0.59–1.26)
CC19/360.90 (0.43–1.89)27/261.69 (0.78–3.68)
AC/CC130/1521.01 (0.71–1.43)141/1570.94 (0.65–1.36)
≥300 μgAA47/831.0 (reference)42/691.0 (reference)
AC43/611.09 (0.62–1.90)44/581.10 (0.61–2.00)
CC3/130.64 (0.14–2.98)6/170.89 (0.27–2.95)
AC/CC46/741.05 (0.61–1.82)50/751.08 (0.61–1.91)
MTRR 66A>GNoneAA57/631.0 (reference)56/611.0 (reference)
AG135/1460.89 (0.55–1.45)126/1480.73 (0.45–1.19)
GG63/1040.74 (0.43–1.27)71/811.05 (0.60–1.82)
AG/GG198/2500.82 (0.51–1.31)197/2290.84 (0.53–1.33)
≥300 μgAA24/321.0 (reference)22/291.0 (reference)
AG51/690.65 (0.32–1.34)50/650.74 (0.36–1.54)
GG17/600.34 (0.15–0.79)19/510.47 (0.20–1.10)
AG/GG68/1290.53 (0.27–1.06)69/1160.65 (0.33–1.30)
  • aAll numbers are before genotype correction imputation (cases/controls where mother took >0 and <300 μg folic acid are excluded, Ns for individual polymorphisms may vary due to sample fails).

  • bORs adjusted for matching variables, mother's age group, parental education, birth order, and ethnicity, and each main effect corrected for genotype error.