Table 1.

Height and overall adiposity associations with ER+PR+ breast cancer in premenopausal women, by ethnicity

AllHispanicsNHWs
ER+PR+ casesControlsER+PR+ casesControlsER+PR+ casesControls
(n = 575)(n = 1,418)(n = 285)(n = 765)(n = 290)(n = 653)
nnORa (95% CI)nnORa (95% CI)nnORb (95% CI)
Current height (cm)c,d
 Q1: <155.51103541.0933091.017451.0
 Q2: 155.5–160.01393571.12 (0.82–1.52)802291.07 (0.74–1.54)591281.14 (0.59–2.21)
 Q3: 160.1–165.41713511.39 (1.02–1.89)811611.41 (0.97–2.06)901901.23 (0.65–2.34)
 Q4: >165.41553541.26 (0.90–1.77)31641.34 (0.80–2.23)1242901.20 (0.64–2.25)
Ptrend = 0.09Ptrend = 0.08Ptrend = 0.61
Current height (cm)d,e
 Quartile 1551891.0761731.0
 Quartile 2621970.98 (0.64–1.52)691571.06 (0.70–1.59)
 Quartile 3751881.21 (0.79–1.86)741671.06 (0.71–1.58)
 Quartile 4931891.34 (0.88–2.04)701551.20 (0.79–1.82)
Ptrend = 0.10Ptrend = 0.41
 Per 5 cm1.06 (0.97–1.15)1.04 (0.93–1.17)1.07 (0.95–1.20)
Young-adult BMI (kg/m2)c,f
 Q1: <20.11903371.0591171.01312201.0
 Q2: 20.1–21.71633380.84 (0.64–1.10)831491.09 (0.70–1.69)801890.71 (0.50–1.01)
 Q3: 21.8–24.11203380.66 (0.49–0.88)782100.81 (0.52–1.26)421280.55 (0.36–0.85)
 Q4: >24.1913380.51 (0.37–0.70)602500.53 (0.33–0.84)31880.58 (0.36–0.95)
Ptrend < 0.01Ptrend < 0.01Ptrend < 0.01
Young-adult BMI (kg/m2)f,g
 Quartile 1861821.0941551.0
 Quartile 2991811.22 (0.84–1.78)791570.83 (0.56–1.23)
 Quartile 3501830.69 (0.45–1.06)631560.66 (0.44–0.99)
 Quartile 4451800.59 (0.38–0.93)471560.50 (0.32–0.78)
Ptrend < 0.01Ptrend < 0.01
 Per 5 kg/m20.74 (0.63–0.86)0.76 (0.62–0.93)0.71 (0.55–0.93)
Current BMI (kg/m2)h
 <25.02945761.01192121.01783641.0
 25.0–29.91484460.69 (0.53–0.88)842860.60 (0.42–0.86)641600.79 (0.55–1.13)
 ≥30.01333940.67 (0.51–0.87)822650.63 (0.44–0.92)511290.74 (0.50–1.10)
Ptrend < 0.01Ptrend = 0.01Ptrend = 0.10
 Per 5 kg/m20.86 (0.78–0.94)0.81 (0.71–0.92)0.92 (0.82–1.05)
Weight gain (kg)c,i
 Q1: <6.81703491.0751541.0951951.0
 Q2: 6.8–11.3692220.66 (0.47–0.92)361240.62 (0.38–1.01)33980.67 (0.41–1.09)
 Q3: 11.3–19.81393500.83 (0.63–1.10)672060.73 (0.48–1.09)721440.99 (0.66–1.47)
 Q4: >19.81243070.80 (0.59–1.07)641780.78 (0.51–1.19)601290.85 (0.56–1.30)
Ptrend = 0.21Ptrend = 0.30Ptrend = 0.68
Weight gain (kg)i,j
 Quartile 1791661.0601361.0
 Quartile 2461610.62 (0.40–0.96)561330.94 (0.60–1.48)
 Quartile 3541660.77 (0.50–1.18)691401.06 (0.68–1.66)
 Quartile 4631690.82 (0.54–1.24)741560.95 (0.62–1.48)
Ptrend = 0.45Ptrend = 0.96
 Per 5 kg0.98 (0.94–1.03)0.96 (0.89–1.04)1.01 (0.94–1.07)
Young-adult BMI (kg/m2)f,k and current BMI (kg/m2)h
 <21.8/<252424361.0891361.01533001.0
 <21.8/25–25.9831850.82 (0.59–1.12)38980.68 (0.42–1.10)45850.95 (0.62–1.47)
 <21.8/≥3028560.89 (0.54–1.47)15320.85 (0.42–1.74)13240.97 (0.47–2.00)
 ≥21.8/<25481130.80 (0.54–1.18)29640.78 (0.45–1.34)19490.77 (0.42–1.39)
 ≥21.8/25–25.9632450.52 (0.37–0.73)451770.47 (0.30–0.74)18680.55 (0.31–0.97)
 ≥21.8/≥301003180.58 (0.43–0.78)642190.53 (0.35–0.81)36990.66 (0.42–1.05)
Pinteraction = 0.73Pinteraction = 0.95Pinteraction = 0.81
  • aORs and 95% CIs, adjusted for age (years, continuous), study (SFBCS, 4-CBCS), ethnicity/English language acculturation (low, moderate, high, and NHW), education (less than high school, high school graduate, after high school education), family history of breast cancer in first-degree relatives (no or yes), age at menarche (<12, 12, 13, ≥14), number of full-term pregnancies (nulliparous, 1–2, 3–4, ≥5), age at first full-term pregnancy (<20, 20–24, 25–29, ≥30, nulliparous), lifetime number of months of breastfeeding (nulliparous, 0, 1–6, 7–12, 13–24, >24), hormonal contraception use (never, former, current), and average alcohol consumption in reference year (g/d; 0, 0.1–4.9, 5–9.9, 10–19.9, ≥20).

  • bAdjusted for all variables above except English language acculturation.

  • cBased on quartiles among all premenopausal controls.

  • dBased on measured height at interview (or self-reported adult height when measured height was not available).

  • eBased on ethnicity-specific quartiles among premenopausal controls in each ethnic group. Quartile cut points by ethnicity are <152.7, 152.7–156.9, 157.0–161.1, and >161.1 for Hispanics, and <160.0, 160.0–164.5, 164.6–168.9, and >168.9 for NHWs.

  • fBased on self-reported averaged weight at age 15 and age 30 for 4-CBCS cases and controls, self-reported weight in the 20s for SFBCS cases and controls (between ages 25–30 for cases diagnosed from April 1995 to April 1998 and matched controls and between ages 20–29 for cases diagnosed from May 1998 to April 2002 and matched controls), and measured height at interview (or self-reported adult height when measured height was not available).

  • gBased on ethnicity-specific quartiles among premenopausal controls in each ethnic group. Quartile cut points by ethnicity are <20.9, 20.9–22.9, 23.0–25.3, and >25.3 for Hispanics, and <19.4, 19.4–20.8, 20.9–22.7, and >22.7 for NHWs.

  • hBased on self-reported weight in reference year (or measured weight at interview when self-reported weight in reference year was not available) and measured height at interview (or self-reported adult height when measured height was not available).

  • iBased on self-reported weight in reference year (or measured weight at interview when self-reported weight was not available) minus self-reported young-adult weight; excludes 62 premenopausal ER+PR+ cases and 125 premenopausal controls who lost weight.

  • jBased on ethnicity-specific quartiles among premenopausal controls in each ethnic group. Quartile cut points by ethnicity are <7.5, 7.5–12.5, 12.6–20.4, and >20.4 for Hispanics, and <5.0, 5.0–10.2, 10.3–18.1, and >18.1 for NHWs.

  • kBased on the median among all premenopausal controls.