Table 3.

Abdominal adiposity associations with breast cancer risk in premenopausal women measured <12 months after diagnosis/selection, by ethnicity

AllHispanicsNHWs
CasesControlsCasesControlsCasesControls
(n = 199)(n = 937)(n = 71)(n = 561)(n = 128)(n = 376)
nnORa (95% CI)nnORa (95% CI)nnORb (95% CI)
Waist (cm)c
 T1: <79.5823101.0161271.0661831.0
 T2: 79.5–91.4643081.16 (0.81–1.66)322041.79 (0.83–3.86)321040.85 (0.47–1.53)
 T3: >91.4533181.29 (0.91–1.84)232291.98 (0.74–5.27)30890.90 (0.38–2.13)
Ptrend = 0.34Ptrend = 0.17Ptrend = 0.72
Waist (cm)d
 Tertile 1251841.0401241.0
 Tertile 2241861.51 (0.74–3.08)471251.20 (0.68–2.12)
 Tertile 3221902.27 (0.92–5.61)411271.06 (0.48–2.37)
Ptrend = 0.07Ptrend = 0.81
 Per 2 cm1.03 (0.99–1.08)1.09 (1.02–1.16)0.99 (0.93–1.05)
Hip (cm)c
 T1: <101.1723111.0271651.0451461.0
 T2: 101.1–111.1693081.06 (0.74–1.50)231910.94 (0.47–1.88)461171.20 (0.69–2.07)
 T3: >111.1583181.27 (0.91–1.79)212050.95 (0.39–2.36)371131.13 (0.51–2.51)
Ptrend = 0.27Ptrend = 0.90Ptrend = 0.68
Hip (cm)e
 Tertile 1281851.0421251.0
 Tertile 2231861.11 (0.55–2.21)441241.06 (0.61–1.85)
 Tertile 3201901.16 (0.48–2.85)421271.06 (0.49–2.33)
Ptrend = 0.73Ptrend = 0.86
 Per 2 cm1.02 (0.98–1.07)1.04 (0.97–1.11)1.00 (0.94–1.07)
Waist-to-hip ratioc
 T1: <0.77813081.0101071.0712011.0
 T2: 0.77–0.83603091.35 (0.95–1.93)242041.60 (0.66–3.86)361051.01 (0.59–1.72)
 T3: >0.83583191.34 (0.92–1.95)372492.67 (1.10–6.49)21700.86 (0.44–1.68)
Ptrend = 0.75Ptrend = 0.02Ptrend = 0.71
Waist-to-hip ratiof
 Tertile 1221851.0521251.0
 Tertile 2211851.04 (0.50–2.16)331230.63 (0.36–1.11)
 Tertile 3281901.96 (0.95–4.06)431280.73 (0.41–1.33)
Ptrend = 0.06Ptrend = 0.29
 Per 0.11.12 (0.84–1.51)1.70 (1.03–2.81)0.89 (0.61–1.31)
Waist-to-height ratioc
 T1: <0.50883071.0131011.0752061.0
 T2: 0.50–0.58563101.22 (0.85–1.75)292162.13 (0.90–5.05)27940.76 (0.41–1.41)
 T3: >0.58553191.40 (0.97–2.03)292433.57 (1.25–10.18)26760.73 (0.29–1.79)
Ptrend = 0.48Ptrend = 0.02Ptrend = 0.42
Waist-to-height ratiog
 Tertile 1291851.0461241.0
 Tertile 2221841.19 (0.59–2.40)441240.83 (0.47–1.48)
 Tertile 3201911.46 (0.59–3.60)381280.64 (0.28–1.48)
Ptrend = 0.42Ptrend = 0.30
 Per 0.11.13 (0.79–1.61)1.92 (1.12–3.28)0.72 (0.43–1.21)
  • aORs and 95% CIs, adjusted for age (years, continuous), study (SFBCS, 4-CBCS), ethnicity/English language acculturation (low, moderate, high, and NHW), education (less than high school, high school graduate, after high school education), family history of breast cancer in first-degree relatives (no or yes), age at menarche (<12, 12, 13, ≥14), number of full-term pregnancies (nulliparous, 1–2, 3–4, ≥5), age at first full-term pregnancy (<20, 20–24, 25–29, ≥30, nulliparous), lifetime number of months of breastfeeding (nulliparous, 0, 1–6, 7–12, 13–24, >24), hormonal contraception use (never, former, current), average alcohol consumption in reference year (g/d; 0, 0.1–4.9, 5–9.9, 10–19.9, ≥20), and current BMI (continuous).

  • bAdjusted for all variables above except English language acculturation.

  • cBased on tertiles among premenopausal controls measured <12 months after selection into the study.

  • dBased on ethnicity-specific tertiles among premenopausal controls measured <12 months after selection into the study in each ethnic group. Tertile cut points by ethnicity are <82.9, 82.9–94.0, and >94.0 for Hispanics and <74.3, 74.3–86.5, and >86.5 for NHWs.

  • eBased on ethnicity-specific tertiles among premenopausal controls measured <12 months after selection into the study in each ethnic group. Tertile cut points by ethnicity are <101.9, 101.9–111.8, and >111.8 for Hispanics and <99.7, 99.7–109.2, and >109.2 for NHWs.

  • fBased on ethnicity-specific tertiles among premenopausal controls measured <12 months after selection into the study in each ethnic group. Tertile cut points by ethnicity are <0.80, 0.80–0.85, and >0.85 for Hispanics and <0.74, 0.74–0.80, and >0.80 for NHWs.

  • gBased on ethnicity-specific tertiles among premenopausal controls measured <12 months after selection into the study in each ethnic group. Tertile cut points by ethnicity are <0.53, 0.53–0.60, and >0.60 for Hispanics and <0.45, 0.45–0.53, and >0.53 for NHWs.