Table 3.

Child's folate pathway genotypes and risk of ALL by immunophenotype and cytogenetic subtype

PreB cell (n = 346)T cell (n = 37)ETV6-Runx-1 [t(12, 21); (n = 61)]Hyperdiploidy (n = 115)Trisomy or higher 21 (n = 67)
PolymorphismGenotypeORa (95% CI)ORa (95% CI)ORa (95% CI)ORa (95% CI)ORa (95% CI)
MTHFR 677 C>TCC1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
CT1.21 (0.90–1.63)1.39 (0.63–3.06)0.96 (0.53–1.72)1.48 (0.95–2.30)2.19 (1.22–3.93)
TT1.11 (0.68–1.83)2.57 (0.92–7.19)0.42 (0.12–1.52)0.86 (0.37–1.98)0.73 (0.20–2.65)
CT/TT1.19 (0.90–1.58)1.63 (0.78–3.39)0.85 (0.48–1.50)1.37 (0.89–2.11)1.95 (1.10–3.47)
MTHFR 1298 A>CAA1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
AC1.00 (0.74–1.35)1.58 (0.74–3.36)1.41 (0.78–2.56)0.81 (0.52–1.28)1.05 (0.58–1.87)
CC0.87 (0.46–1.63)1.20 (0.29–4.91)1.00 (0.29–3.39)1.18 (0.55–2.56)1.27 (0.47–3.45)
AC/CC0.98 (0.74–1.31)1.51 (0.73–3.12)1.35 (0.76–2.40)0.86 (0.56–1.32)1.07 (0.62–1.85)
MTRR 66A>GAA1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
AG0.83 (0.57–1.21)0.87 (0.33–2.30)1.25 (0.57–2.74)0.77 (0.45–1.34)0.84 (0.41–1.73)
GG0.58 (0.37–0.89)0.99 (0.33–2.95)0.61 (0.24–1.55)0.46 (0.24–0.90)0.63 (0.27–1.44)
AG/GG0.73 (0.51–1.05)0.88 (0.35–2.26)0.99 (0.46–2.11)0.65 (0.38–1.10)0.79 (0.40–1.58)
MTR 2756 A>GbAA1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
AG/GG1.08 (0.80–1.44)0.63 (0.28–1.39)1.20 (0.66–2.17)0.95 (0.61–1.49)1.25 (0.71–2.19)
MTR 5049 C>ACC1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
CA0.99 (0.72–1.35)1.21 (0.57–2.62)1.24 (0.68–2.27)1.04 (0.65–1.67)1.09 (0.59–1.99)
AA1.05 (0.67–1.65)0.71 (0.19–2.66)0.51 (0.16–1.61)1.34 (0.70–2.55)1.25 (0.53–2.94)
CA/AA1.01 (0.75–1.35)1.12 (0.54–2.35)1.07 (0.60–1.92)1.11 (0.71–1.73)1.14 (0.64–2.03)
CBS 2199 T>CTT1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
TC0.80 (0.57–1.12)1.23 (0.50–3.03)0.93 (0.47–1.84)0.81 (0.50–1.32)0.58 (0.32–1.05)
CC1.25 (0.82–1.89)1.37 (0.46–4.10)1.07 (0.45–2.54)0.92 (0.50–1.72)0.32 (0.12–0.85)
TC/CC0.92 (0.67–1.26)1.30 (0.55–3.07)0.98 (0.52–1.87)0.87 (0.55–1.37)0.53 (0.30–0.92)
CBS 844 Ins 68bWTWT1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
WTIns/InsIns0.80 (0.53–1.19)0.99 (0.37–2.67)0.26 (0.08–0.89)1.63 (0.97–2.73)1.61 (0.83–3.13)
  • aAll ORs adjusted for matching variables (child's age, sex, state of residence), maternal age, child ethnicity, birth order, parental education, and corrected for genotype method discordance.

  • bN for homozygous mutants insufficient to produce separate OR.