Table 3.

MECC association results from logistic regression adjusted for age, sex, and principal components 1–2 for Axiom miRNA Target Site Genotyping Array markers previously studied as miRNA-related variants

SNPCHRPositionGeneA1aPublished ORPublished PMECC ORMECC SEbMECC P
rs1051690c197116963INSRT1.860.051.380.150.03
rs1368439c5158742014IL12BG1.170.650.800.120.06
rs11515d921968199CDKN2AG1.160.711.140.120.30
rs1126547e314186757XPCC1.130.731.140.130.32
rs3135500c1650766886NOD2A1.220.071.090.090.37
rs1131445c1581601782IL16C0.991.000.930.090.41
rs1131445d1581601782IL16C2.210.0040.930.090.41
rs1051208d312625747RAF1T1.110.850.900.140.44
rs4596e1118388128GTF2H1C0.790.030.930.100.44
rs2229090e314187345XPCC0.910.381.080.120.54
rs17281995c3121839641CD86C2.930.011.050.120.66
rs11677c120301964PLA2G2AT1.020.971.060.140.70
rs7356e128218100RPA2C1.330.041.020.090.81
rs1803541e2128014913ERCC3T0.960.700.970.140.86
rs16870224c540692940PTGER4A2.310.140.990.120.94
rs16870224d540692940PTGER4A0.290.110.990.120.94
rs4781563e1614045399ERCC4A0.680.091.000.100.97
rs916055c174534834ALOX15C0.980.911.000.100.98
rs743554d1773754248ITGB4A0.760.36NANANA

NOTE: Data row 1 shows replication of a variant in INSR that was suggestively associated with colorectal cancer risk in prior publications by Landi et al. in 2008 and 2011 [OR (95% CI), 1.86 (0.99–3.50); P = 0.052].

  • aA1, effect allele for the corresponding ORs.

  • bSE, standard error of the beta estimate.

  • cLandi et al. 2008 (18).

  • dAzimzadeh et al. 2012 (19).

  • eNaccarati et al. 2012 (20).