Table 3.

HRs and 95% CIs for estimated dietary intake of acrylamide (energy-adjusted using the residual method) and EOC in EPIC

Energy-adjusted acrylamide intake, μg/d
Quintiles
10-μg increments<14.614.7–19.619.7–24.424.5–32.332.4–222.4Trend test Pa
EOC
n cases1,191221207219280264
 HR (95% CI)b1.02 (0.96–1.09)1.00 (ref)0.89 (0.72–1.11)0.87 (0.70–1.09)1.08 (0.87–1.34)0.97 (0.76–1.23)0.73
Borderline
n cases961519272312
 HR (95% CI)b0.90 (0.71–1.13)1.00 (ref)1.29 (0.60–2.76)1.75 (0.83–3.69)1.55 (0.71–3.42)0.82 (0.32–2.08)0.56
Invasive
n cases1,095206188192257252
 HR (95% CI)b1.03 (0.97–1.10)1.00 (ref)0.87 (0.69–1.08)0.81 (0.64–1.02)1.04 (0.83–1.31)0.97 (0.75–1.24)0.60
Invasive
 Serous
  n cases582124103102132121
  HR (95% CI)b0.98 (0.89–1.07)1.00 (ref)0.78 (0.59–1.05)0.72 (0.53–0.98)0.94 (0.69–1.28)0.84 (0.60–1.17)0.72
 Not otherwise specified
  n cases2492845386474
  HR (95% CI)b1.09 (0.97–1.23)1.00 (ref)1.44 (0.83–2.50)1.10 (0.61–1.96)1.54 (0.88–2.69)1.63 (0.92–2.90)0.11
 Serous combined with not otherwise specified
  n cases831152148140196195
  HR (95% CI)b1.02 (0.95–1.10)1.00 (ref)0.90 (0.70–1.17)0.79 (0.60–1.03)1.05 (0.81–1.37)1.00 (0.75–1.33)0.52
 Endometrioid
  n cases1182720192923
  HR (95% CI)b1.12 (0.93–1.36)1.00 (ref)0.77 (0.40–1.49)0.67 (0.33–1.34)1.01 (0.51–1.98)0.72 (0.34–1.55)0.61
 Clear cell
  n cases5168131212
  HR (95% CI)b0.92 (0.69–1.23)1.00 (ref)1.42 (0.42–4.73)1.77 (0.54–5.80)1.42 (0.41–4.91)1.03 (0.29–3.74)0.61
 Endometrioid combined with clear cell
  n cases1693328324135
  HR (95% CI)b1.05 (0.89–1.23)1.00 (ref)0.89 (0.50–1.57)0.88 (0.49–1.58)1.07 (0.59–1.92)0.76 (0.40–1.45)0.45
 Mucinous
  n cases791611131920
  HR (95% CI)b1.17 (0.95–1.44)1.00 (ref)0.68 (0.29–1.60)0.69 (0.29–1.65)1.11 (0.48–2.55)1.33 (0.54–3.28)0.21
  • aAll P values for trend are based on the quintile medians.

  • bStratified by age at recruitment and center. Adjusted for total energy intake (1,000 kcal/d), BMI (kg/m2), smoking status (never smokers, current pipe or cigar or occasional smokers, current cigarette smokers: 1–15, 16–25, or ≥26 cigarettes per day, former cigarette smokers who quit >20, 11–20, or ≤10 years before recruitment), OC use (never, ever, unknown), menopause status combined with age at menopause (premenopausal, perimenopausal, postmenopausal with: <45, 45–49, 50–52, 53–55, ≥56 years, postmenopausal women with missing age at menopause), and parity (nulliparous, 1, 2, ≥3, parous but with missing number of full-term pregnancies, unknown).