SNP with smallest P for interaction with total, dietary, or supplemental calcium for colorectal cancer risk
| Interaction resultsb,c | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Calcium analysis | SNP with smallest P for interaction | Locus | Position (bp)a | Function class | Genetic region | Minor allele | Alt allele | MAF | Mean Rsq | Variable | OR-int (95% CI) | P | Phet |
| Total | rs1933755 | 6q23.1 | 130925767 | Intergenic | TMEM200A/EPB41L2 | C | T | 0.10 | 0.93 | Total | 0.84 (0.78–0.90) | 1.5E−06 | 4.1E−01 |
| Dietary | 0.86 (0.80–0.92) | 5.2E−05 | 3.2E−01 | ||||||||||
| Suppl | 0.81 (0.65–1.02) | 7.4E−02 | 5.5E−01 | ||||||||||
| Dietary | rs6855885 | 4q22.1 | 92039007 | Intronic | FAM190A | A | G | 0.50 | 0.94 | Total | 1.09 (1.04–1.13) | 9.0E−05 | 2.5E−01 |
| Dietary | 1.11 (1.06–1.16) | 1.9E−06 | 5.5E−01 | ||||||||||
| Suppl | 0.93 (0.81–1.07) | 3.0E−01 | 2.4E−01 | ||||||||||
| Supplemental | rs1028166 | 4q34.3 | 182813298 | Intergenic | AGA/TENM3 | G | A | 0.31 | 0.85 | Total | 1.07 (1.02–1.12) | 6.7E−03 | 3.8E−01 |
| Dietary | 1.02 (0.97–1.07) | 5.2E−01 | 7.4E−01 | ||||||||||
| Suppl | 1.49 (1.27–1.74) | 7.3E−07 | 2.9E−01 | ||||||||||
Abbreviations: Alt, alternate; MAF, minor allele frequency; OR-int, odds ratio for interaction; Phet, P for heterogeneity across studies; Rsq, imputation Rsq.
↵aOn the basis of NCBI build 37 data.
↵bCorresponds to each additional copy of the minor allele (i.e., assuming additive genetic effects) and each quartile increase in calcium intake (total, dietary) or ≥500 versus <500 mg/d (supplemental). Genotyped SNPs were modeled as 0, 1, or 2 copies of the minor allele; imputed SNPs were modeled as the expected number of copies of the minor allele (the genotype “dosage”; refs. 3, 7).
↵cOn the basis of multivariable logistic regression adjusted for age (continuous), sex (F/M), study center (indicators), energy consumption (continuous), first 3 principal components of genetic ancestry (continuous), SNP main effect, and calcium main effect.