Table 2.

Reproducibility of serum estrogens and estrogen metabolites, measured in total (conjugated + unconjugated) and unconjugated forms, in 10 premenopausal women, 5 postmenopausal women, and 5 men

Premenopausal womenPostmenopausal womenMen
Overall CVsRange of individual CVsOverall CVsRange of individual CVsOverall CVsRange of individual CVs
Estrone0.30%0.06%–0.54%0.04%0.01%–0.07%0.03%0.02%–0.04%
Unconjugated estrone0.22%0.07%–0.49%0.09%0.02%–0.15%0.10%0.07%–0.15%
Estradiol0.88%0.08%–2.21%0.12%0.04%–0.22%0.12%0.04%–0.24%
Unconjugated estradiol0.53%0.03%–1.18%0.27%0.01%–0.50%0.12%0.06%–0.19%
2-Hydroxyestrone0.24%0.08%–0.30%0.05%0.02%–0.07%0.05%0.01%–0.07%
2-Hydroxyestradiol0.43%0.09%–1.03%0.14%0.01%–0.22%0.16%0.03%–0.27%
2-Methoxyestrone0.17%0.04%–0.43%0.17%0.03%–0.23%0.14%0.06%–0.19%
Unconjugated 2-methoxyestrone0.40%0.09%–0.93%0.26%0.03%–0.40%0.52%0.23%–0.97%
2-Methoxyestradiol0.32%0.08%–0.56%0.28%0.02%–0.52%0.35%0.19%–0.54%
Unconjugated 2-methoxyestradiol0.85%0.15%–2.17%0.35%0.03%–0.44%1.38%0.31%–2.11%
2-Hydroxyestrone-3-methyl ether0.50%0.09%–1.01%0.54%0.14%–0.75%0.49%0.19%–0.77%
4-Hydroxyestrone0.25%0.04%–0.62%0.45%0.11%–0.93%5.64%0.04%–11.59%
4-Methoxyestrone1.15%0.15%–2.57%0.57%0.33%–0.77%0.80%0.46%–1.46%
4-Methoxyestradiol0.84%0.24%–1.72%1.34%0.33%–2.57%1.66%0.74%–3.06%
16α-Hydroxyestrone0.28%0.06%–0.54%0.10%0.01%–0.16%0.08%0.04%–0.11%
Estriol0.26%0.02%–0.59%0.02%0.01%–0.02%0.02%0.01%–0.03%
Unconjugated estriol0.26%0.09%–0.42%0.12%0.06%–0.18%0.28%0.04%–0.60%
16-Ketoestradiol0.31%0.02%–0.78%0.40%0.04%–0.87%0.10%0.05%–0.14%
16-Epiestriol0.31%0.06%–0.63%0.47%0.23%–0.72%0.55%0.15%–0.75%
17-Epiestriol0.41%0.11%–0.78%1.73%0.19%–3.35%1.35%0.31%–1.92%