Table 1.

Serum concentrationsa of 15 estrogens and estrogen metabolites (EM), in total (conjugated + unconjugated) and unconjugated forms (pmol/L), in 20 premenopausal women, 15 postmenopausal women, and 10 men

Premenopausal womenPostmenopausal womenMen
Interdecile rangeInterdecile rangeInterdecile range
Median10th90thMedian10th90thMedian10th90th
All EM5,406.42,215.41,2967.41,463.9589.64,384.61,644.01044.94715.9
 Conjugated EM3,143.41,007.99,083.1828.8403.92,517.4939.0718.43039.9
 Unconjugated EM609.8296.21,277.9170.882.0404.0199.6122.0334.0
Parent estrogens2,517.1785.67,422.0533.2169.42,055.3723.4413.82147.9
 Estrone1,986.2538.26,712.3480.3136.01,611.5614.5379.31962.6
 Unconjugated estrone186.784.6362.976.935.6170.377.647.9154.6
 Estradiol432.2199.61,094.464.820.7230.5133.133.4211.6
 Unconjugated estradiol267.4126.9666.016.75.491.554.016.387.8
2-Pathway EM777.5353.72,028.0266.984.9733.1280.3122.8704.8
 2-Hydroxyestrone471.4169.51,247.2127.646.2351.1134.266.3522.7
 2-Hydroxyestradiol79.524.9235.535.712.8110.934.115.183.5
 2-Methoxyestrone164.832.5293.845.713.486.250.911.7124.9
 Unconjugated 2-methoxyestrone55.611.3127.616.97.626.112.25.221.6
 2-Methoxyestradiol33.87.5105.916.27.169.714.77.850.8
 Unconjugated 2-methoxyestradiol8.82.520.34.11.912.44.31.25.2
 2-Hydroxyestrone-3-methyl ether25.810.962.212.32.624.011.43.224.7
4-Pathway EM91.636.6208.830.512.075.932.823.593.0
 4-Hydroxyestrone63.925.7151.522.56.961.721.716.285.0
 4-Methoxyestrone10.12.333.74.53.410.85.32.411.4
 4-Methoxyestradiol7.23.116.03.11.65.72.91.46.1
16-Pathway EM1,704.6750.04,599.2548.2314.11,249.4555.9484.01770.2
 16α-Hydroxyestrone251.798.7642.974.037.6227.872.436.0310.7
 Estriol1,089.2405.22,894.2427.7247.8846.8441.5292.71091.3
 Unconjugated estriol90.830.1133.652.518.975.046.825.874.2
 16-Ketoestradiol291.1105.4718.383.624.0179.877.229.5255.8
 16-Epiestriol73.032.1145.624.83.563.232.43.369.3
 17-Epiestriol45.910.5131.121.71.475.616.31.354.5
  • aMedians and ranges were calculated using a single, arbitrarily selected aliquot for each of the 10 premenopausal women, 5 postmenopausal women, and 5 men whose samples were assayed in replicate in the laboratory reproducibility study, and the single aliquot assayed for the additional 10 premenopausal women, 10 postmenopausal women, and 5 men.