Table 3.

Associationsa between hormone levels and TDLU counts among women in the KTB

PremenopausalbPostmenopausalc
Serum hormone levelsNRR (95% CI)PtrendNRR (95% CI)Ptrend
Estradiol236152
T2 vs. T10.97 (0.88–1.08)0.86 (0.69–1.08)
T3 vs. T10.88 (0.80–0.97)0.011.61 (1.32–1.97)<0.0001
Free estradiol (%)206130
T2 vs. T10.87 (0.78–0.98)1.35 (1.09–1.67)
T3 vs. T10.89 (0.79–1.00)0.050.87 (0.67–1.11)0.45
Testosterone232148
T2 vs. T10.94 (0.85–1.04)1.18 (0.97–1.44)
T3 vs. T10.97 (0.88–1.08)0.601.32 (1.09–1.59)0.0043
Free testosterone (%)205130
T2 vs. T10.87 (0.78–0.98)1.35 (1.09–1.67)
T3 vs. T10.89 (0.80–1.00)0.050.86 (0.67–1.11)0.45
SHBG210134
T2 vs. T10.93 (0.84–1.05)1.54 (1.22–1.93)
T3 vs. T11.04 (0.93–1.16)0.511.14 (0.89–1.45)0.54
Progesterone237148
T2 vs. T10.96 (0.87–1.06)0.88 (0.71–1.08)
T3 vs. T10.80 (0.72–0.89)< 0.00010.23d
Prolactin237152
T2 vs. T10.85 (0.76–0.95)1.28 (1.04–1.58)
T3 vs. T11.18 (1.07–1.31)0.00051.29 (1.04–1.59)0.02

Abbreviations: T1, tertile one; T2, tertile two; T3, tertile three.

  • aOnly results for the Poisson count models from the zero-inflated Poisson models are shown, as no results were significant in the binomial logit models. Only Ptrend < 0.0031 were significant and 0.0031 < Ptrend ≤ 0.05 were suggestive, after Bonferroni correction.

  • bAdjusted for parity/age at first birth and percent fat on tissue slide.

  • cAdjusted for parity/age at first birth, years since menopause, and percent fat on tissue slide.

  • dRR, 95% CIs, and P value for detectable versus not detectable levels of progesterone.