Risk and protective HLA associations in cHL
| HLA gene | Allele | Association | Populationa | Reference |
|---|---|---|---|---|
| HLA-A | A*01 | Risk | EBV+ cHL | (24–26) |
| A*02 | Protective | EBV+ cHL | (24–26) | |
| A*02:07 | Risk | Chinese, EBV+ cHL | (27) | |
| A*02:07 | Protective | Chinese, EBV− cHL | (27) | |
| HLA-B | B*05 | Risk | cHL overall | (26) |
| B*37 | Risk | EBV+ cHL | (26) | |
| HLA-DRB1 | DRB1*04:04 | Protective | NS cHL | (25) |
| DRB1*07:01 | Protective | cHL overall, NS cHL | (26, 29, 30) | |
| DRB1*10 | Risk | EBV+ cHL | (26) | |
| DRB1*11:04 | Risk | NS cHL | (25) | |
| DRB1*11/12 (DR5) | Risk | EBV− cHL | (26) | |
| DRB1*15:01 | Risk | cHL overall, NS cHL | (29, 30) | |
| DRB1*15/16 (DR2) | Risk | EBV− cHL | (26) | |
| HLA-DQA1 | DQA1*02:01 | Protective | cHL overall, NS cHL | (29, 30) |
| HLA-DQB1 | DQB1*03:03 | Protective | cHL overall, NS cHL | (29, 30) |
| DQB1*06:02 | Risk | cHL overall, NS cHL | (29, 30) | |
| HLA-DPB1 | DPB1*03:01 | Risk | cHL overall, Females, NS cHL | (29, 31–33) |
| DPB1*11:01 | Protective | NS cHL | (29, 31) | |
| DPB1*34:01 | Risk | Males-MC cHL | (31) |
↵aAll the case and control populations are of Caucasian ethnicity unless otherwise specified.