Table 3.

Geometric means (95% confidence interval) of 1,3-butadiene metabolites stratified by GSTT1 CNV and race/ethnicity (adjusted for age and sex)

AllWhitesNative HawaiiansJapanese Americans
GSTT1 copy number genotypenGeometric meana (95% CI)nGeometric meana (95% CI)nGeometric meana (95% CI)nGeometric meana (95% CI)P
MHBMA
 1/112811.1 (9.5–13.0)5911.8 (9.5–14.5)4910.5 (8.3–13.3)2011.1 (7.7–15.9)0.79
 1/02716.7 (6.1–7.4)866.6 (5.6–7.9)976.6 (5.6–7.8)886.9 (5.8–8.3)0.92
 0/01842.3 (2.1–2.6)493.4 (2.7–4.3)471.7 (1.3–2.1)b882.2 (1.9–2.7)b0.0001
P<0.0001<0.0001<0.0001<0.0001
DHBMA
 1/1128529.5 (467.2–600.1)59564.5 (478.5–665.9)49522.1 (434.7–627.0)20503.7 (379.3–668.9)0.73
 1/0271535.8 (496.1–578.7)86536.3 (467.8–614.9)97509.4 (447.0–580.5)88563.1 (491.1–645.5)0.59
 0/0184478.2 (433.8–527.2)49573.0 (477.5–687.7)47417.9 (346.8–503.6)b88456.6 (398.6–523.1)0.05
P0.1810.8180.1630.099
MHBMA/(MHBMA + DHBMA) ratio
 1/11280.020 (0.017–0.024)590.020 (0.016–0.025)490.019 (0.015–0.025)200.021 (0.015–0.032)0.91
 1/02710.012 (0.011–0.014)860.012 (0.010–0.015)970.013 (0.011–0.015)880.012 (0.010–0.015)0.90
 0/01840.005 (0.004–0.006)490.006 (0.005–0.008)470.004 (0.003–0.005)b880.005 (0.004–0.006)0.08
P<0.0001<0.0001<0.0001<0.0001
  • aAdjusted for age, sex, BMI (natural log), and log-nicotine equivalents (natural log).

  • bP < 0.05 when compared with whites.