Table 1.

A comparison between CE FL-DNA and RT FL-DNA to evaluate the best valid method to quantify FL-DNA from stool samples in detecting tumor and tumor and high-risk adenoma patients

CE FL-DNART FL-DNA
Cutoffs (ng)CRCOthersa% Sensitivity (95% CI)% Specificity (95% CI)% Accuracy (95% CI)CRCOthersa% Sensitivity (95% CI)% Specificity (95% CI)% Accuracy (95% CI)
PositivePositive
≥102112391(73–97)44 (37–50)48 (42–54)174474 (53–87)80 (74–85)79 (74–84)
≥15187178 (58–90)67 (61–73)68 (62–74)162970 (49–84)87 (82–91)85 (80–89)
≥20164670 (49–84)79 (73–84)78 (72–83)141961 (41–78)91 (87–85)88 (84–92)
≥25133457 (37–74)84 (79–89)82 (76–86)131257 (37–74)94 (91–97)91 (87–94)
≥30122152 (33–71)90 (86–94)87 (82–90)13557 (37–74)98 (95–99)94 (90–96)
CRC + HRAOthersbCRC + HRAOthersb
PositivePositive
≥104010471 (58–82)44 (37–51)50 (44–55)233841 (29–54)79 (73–85)71 (65–76)
≥15276248 (36–61)66 (59–73)62 (56–68)222339 (28–52)88 (82–92)76 (71–81)
≥20233941 (29–54)79 (72–84)70 (64–76)171630 (20–43)91 (86–95)77 (72–82)
≥25182932 (21–45)84 (78–89)72 (66–77)151027 (17–40)95 (90–97)79 (74–84)
≥30151827 (17–40)90 (85–94)76 (70–81)15327 (17–40)98 (95–99)82 (76–86)

NOTE: Sensitivity, true-positive rates; specificity, true-negative rates; accuracy, number of true positive plus number of true negative, divided by the total series.

Abbreviations: CRC, colorectal cancer patients; HRA, high-risk adenoma patients.

  • aOther, high- and low-risk adenomas and healthy subjects.

  • bOther, low-risk adenomas and healthy subjects.