Table 3.

Extension of Spitz lung cancer risk models using CBMN assay endpoints among never, former, and current smokers in the model building (MDACC) population

BN-MN modela
VariablesOR (95% CI)
Never smokers
 CBMN16.72 (9.01–31.02)
 Second-hand smoke1.12 (0.47–2.68)
 Family history (≥2)b1.06 (0.47–2.43)
Former smokers
 CBMN15.78 (10.16–24.51)
 Emphysema2.14 (0.94–4.90)
 Dusts1.30 (0.64–2.64)
 Family history (≥2)b1.25 (0.73–2.13)
 Quit age: 42–531.23 (0.66–2.27)
 Quit age: ≥541.35 (0.73–2.47)
Current smokers
 CBMN11.44 (7.40–17.68)
 Emphysema4.92 (2.16–11.23)
 Pack year: 28–41.93.66 (1.72–7.76)
 Pack year: 42–57.43.24 (1.52–6.90)
 Pack year: ≥57.55.77 (2.57–12.96)
 Dusts1.47 (0.69–3.11)
 Asbestos1.67 (0.84–3.32)
 Family history (≥1)c1.51 (0.84–2.69)
  • aBN-MN is modeled as continuous variables.

  • bIndividuals with 2 or more first-degree family members with cancer.

  • cIndividuals with 1 or more first-degree family members with a smoking-related cancer.