Table 3.

Baseline mtDNA copy number for cases and controls and mtDNA copy number stratified by time since blood collection

CasesControlsPa
Colorectal cancer
 Number4441,423
 Geometric mean (95% CI)0.277 (0.269–0.285)0.288 (0.284–0.293)0.0153
Colon cancer
 Number2761,382
 Geometric mean (95% CI)0.276 (0.267–0.286)0.288 (0.284–0.293)0.0323
Rectal cancer
 Number1681,252
 Geometric mean (95% CI)0.278 (0.266–0.291)0.287 (0.282–0.292)0.1971
Time since blood collection (colorectal cancer)
 <5 years
  Number1771,229
  Geometric mean (95% CI)0.281 (0.269–0.293)0.289 (0.284–0.294)0.2313
 ≥5 years
  Number2671,372
  Geometric mean (95% CI)0.277 (0.267–0.288)0.289 (0.285–0.294)0.0349
  • aP values were derived from the two-way (case–control status and assay batches/plates) ANOVA F test for the case–control difference by using log-transformed data. Bold indicates significantly significant at P < 0.05.