Table 5.

Associations of two cancer risk variants with IMPC risk, after subjects with the cancer site corresponding to the known association have been removed, or after stratifying by smoking status

Breast cancer SNP rs11249433Breast cancer SNP rs3803662Lung cancer SNP rs578776
SNPCasesControlOR (95% CI)bPCasesControlOR (95% CI)bPCasesControlOR (95% CI)bP
Cancer site removeda8226,5961.15 (1.00–1.31)0.0468416,7121.11 (0.99–1.24)0.0631,1179,0721.18 (1.06–1.30)0.0015
Stratify by smokingc
 Never smokers5094,0271.11 (0.94–1.32)0.205234,1111.10 (0.95–1.26)0.205244,1181.16 (1.00–1.36)0.049
 Ever smokers7965,0341.19 (1.04–1.36)0.018095,1171.15 (1.03–1.29)0.028085,0931.12 (0.99–1.26)0.06
Pheterogeneity by smoking status0.530.630.73
  • aSubjects with the cancer site corresponding to the known association with cancer have been removed.

  • bModels were adjusted for age at diagnosis for the index cancer (continuous), sex (MEC only), study design (WHI only: clinical trial vs. observational study), the most significant principal components.

  • cAdditionally adjusted for pack-years.