Table 3.

Associations (OR; 95% CI) between circulating estrogens and testosterone concentrations and aggressive prostate cancer

Quartile
Hormone measure1234Ptrend
Parent estrogens1.001.39 (0.79–2.46)1.21 (0.68–2.16)0.92 (0.50–1.68)0.70
 Estrone1.001.39 (0.79–2.47)1.36 (0.77–2.42)0.86 (0.47–1.60)0.55
 Estradiol1.001.52 (0.87–2.68)1.13 (0.63–2.02)0.80 (0.43–1.48)0.30
Testosterone1.001.83 (0.88–3.76)1.82 (0.88–3.76)2.96 (1.25–7.00)0.018
Estrogen-to-testosterone ratios
 Total parents:testosterone1.000.81 (0.45–1.46)0.66 (0.35–1.24)0.62 (0.31–1.26)0.16
 Estrone:testosterone1.000.79 (0.44–1.41)0.74 (0.40–1.39)0.64 (0.32–1.27)0.21
 Estradiol:testosterone1.000.48 (0.26–0.89)0.50 (0.26–0.97)0.27 (0.12–0.59)0.003
Mutually adjusted modela
 Estradiol:testosterone1.000.52 (0.28–0.99)0.59 (0.28–1.25)0.35 (0.14–0.89)0.016
 Testosterone1.001.54 (0.80–2.98)1.30 (0.59–2.85)1.64 (0.60–4.47)0.47

NOTE: Adjusted for age at blood draw, BMI, and SHBG. Boldface indicates findings that are statistically significant.

  • aEstimates derived from the same model that is mutually adjusted for testosterone and estradiol:testosterone ratio.