Table 4.

Associations (OR; 95% CI) between circulating sex steroid hormone concentrations and aggressive prostate cancer

Quartile
Estrogen and estrogen metabolism measures1234Ptrend
All estrogens and estrogen metabolites1.001.27 (0.72–2.23)1.28 (0.72–2.27)0.84 (0.46–1.54)0.65
2-Hydroxylation pathway1.001.53 (0.87–2.70)1.27 (0.71–2.28)0.94 (0.51–1.72)0.69
2-Hydroxylation pathway catechols1.001.35 (0.75–2.41)1.63 (0.92–2.87)0.87 (0.47–1.62)0.95
 2-Hydroxyestrone1.001.48 (0.82–2.65)1.49 (0.84–2.64)0.91 (0.49–1.68)0.89
 2-Hydroxyestradiol1.001.23 (0.70–2.16)0.94 (0.52–1.68)0.92 (0.52–1.65)0.79
2-Hydroxylation pathway methylated catechols1.000.54 (0.30–0.98)0.71 (0.41–1.24)0.59 (0.33–1.06)0.14
 2-Methoxyestrone1.000.47 (0.26–0.85)0.65 (0.37–1.13)0.53 (0.29–0.94)0.06
 2-Methoxyestradiol1.001.07 (0.61–1.88)0.96 (0.54–1.70)0.80 (0.44–1.45)0.38
 2-Hydroxyestrone-3-methyl ether1.000.75 (0.42–1.33)0.65 (0.36–1.15)0.82 (0.47–1.44)0.34
4-Hydroxylation pathway1.000.82 (0.46–1.45)1.13 (0.65–1.97)0.63 (0.34–1.14)0.33
 4-Hydroxyestrone1.001.85 (1.05–3.28)1.20 (0.66–2.17)1.07 (0.58–1.97)0.89
4-Hydroxylation pathway methylated catechols1.000.63 (0.32–1.27)0.60 (0.30–1.20)0.54 (0.27–1.10)0.09
 4-Methoxyestrone1.000.48 (0.24–0.97)0.67 (0.34–1.30)0.45 (0.22–0.92)0.08
 4-Methoxyestradiol1.000.58 (0.29–1.17)0.70 (0.36–1.37)0.52 (0.25–1.06)0.12
16-Hydroxylation pathway1.001.02 (0.58–1.81)1.04 (0.59–1.83)0.76 (0.42–1.38)0.43
 16α-Hydroxyestrone1.001.54 (0.86–1.77)1.73 (0.97–3.07)0.84 (0.44–1.58)0.87
 Estriol1.001.00 (0.57–1.75)0.77 (0.43–1.38)0.82 (0.46–1.49)0.33
 17-Epiestriol1.000.73 (0.41–1.30)0.85 (0.48–1.50)0.83 (0.47–1.47)0.72
 16-Ketoestradiol1.001.23 (0.69–2.19)1.41 (0.80–2.48)0.87 (0.47–1.60)0.80
 16-Epiestriol1.000.75 (0.42–1.34)0.75 (0.42–1.34)0.72 (0.41–1.28)0.30
Estrogen metabolic pathway ratios
 2-Hydroxylation pathway:parent estrogens1.001.54 (0.86–2.76)0.85 (0.45–1.60)1.69 (0.95–3.02)0.24
 4-Hydroxylation pathway:parent estrogens1.001.11 (0.62–2.01)1.40 (0.79–2.47)1.14 (0.63–2.05)0.51
 16-Hydroxylation pathway:parent estrogens1.001.32 (0.74–2.35)0.98 (0.55–1.77)0.99 (0.55–1.78)0.71
 2-Hydroxylation pathway:16-hydroxylation pathway1.001.31 (0.71–2.42)1.73 (0.96–3.12)1.53 (0.84–2.79)0.10
 2-Hydroxyestrone:16-hydroxyestrone1.001.24 (0.65–2.37)1.87 (1.01–3.44)2.44 (1.34–4.45)0.001
 2-Hydroxylation pathway:4-hydroxylation pathway1.001.41 (0.78–2.52)1.09 (0.61–1.98)1.29 (0.72–2.31)0.62
 4-Hydroxylation pathway:16-hydroxylation pathway1.001.14 (0.63–2.03)1.18 (0.66–2.10)1.27 (0.71–2.27)0.42
 2-Hydroxylation pathway methylated catechols:catechols1.001.12 (0.65–1.94)0.56 (0.31–1.02)0.73 (0.41–1.30)0.08
 4-Hydroxylation pathway methylated catechols:catechols1.000.60 (0.30–1.22)1.01 (0.52–1.94)0.37 (0.17–0.80)0.08

NOTE: Adjusted for age at blood draw, BMI, and SHBG. Boldface indicates findings that are statistically significant.