Table 3.

Cancer predicted pathways targeted by the three clusters identified by the cluster analysis

miRNA clusterMost significant predicted pathways
Cluster 1Wnt signaling pathway
miR145-5p miR199a-5p miR542-5p miR892b miR1288Steroid biosynthesis
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Hedgehog signaling pathway
Adherens junction
Transcriptional misregulation in cancer
Pathways in cancer
TGFβ signaling pathway
MAPK signaling pathway
Cell cycle
Cluster 2MAPK signaling pathway
miR28-3p miR122* miR138 miR141 miR145-3p miR181c* miR520-3p miR539 miR920ErbB signaling pathway
mTOR signaling pathway
Insulin signaling pathway
PI3K-Akt signaling pathway
Transcriptional misregulation in cancer
Chemokine signaling pathway
Cluster 3MAPK signaling pathway
miR99b miR582-5p miR199b-5pTranscriptional misregulation in cancer
Pathways in cancer