Table 3.

Associations between JCV T-antigen (T-Ag) seroreactivity, colorectal cancer, and colorectal adenomas, Washington County, MD, 1989–2006

JCV T-AgCRC casesControlsAdenoma casesControls
SubgroupSeroreactivityan (%)n (%)OR (95% CI)bn (%)n (%)OR (95% CI)b
OverallLow115 (44.7)126 (49.0)1.00 (reference)61 (49.6)65 (52.8)1.00 (reference)
High142 (55.3)131 (51.0)1.34 (0.89–2.01)62 (50.4)58 (47.2)1.30 (0.70–2.42)
Gender
 MaleLow43 (36.8)40 (34.2)1.00 (reference)26 (42.6)30 (49.2)1.00 (reference)
High74 (63.2)77 (65.8)0.93 (0.51–1.67)35 (57.4)31 (50.8)1.29 (0.55–2.98)
 FemaleLow72 (51.4)86 (61.4)1.00 (reference)35 (56.5)35 (56.5)1.00 (reference)
High68 (48.6)54 (38.6)1.82 (1.00–3.31)27 (43.5)27 (43.5)1.21 (0.45–3.28)
Anatomic site
 DistalLow31 (44.3)33 (47.1)1.00 (reference)42 (60.9)39 (56.5)1.00 (reference)
 colonHigh39 (55.7)37 (52.9)1.35 (0.61–2.99)27 (39.1)30 (43.5)0.77 (0.31–1.93)
 ProximalLow51 (45.9)54 (48.6)1.00 (reference)20 (37.0)29 (53.7)1.00 (reference)
 colonHigh60 (54.1)57 (51.4)1.30 (0.68–2.48)34 (63.0)25 (46.3)2.85 (0.89–9.15)
 RectumLow29 (45.3)35 (54.7)1.00 (reference)15 (57.7)10 (38.5)1.00 (reference)
High35 (54.7)29 (45.3)1.93 (0.81–4.60)11 (42.3)16 (61.5)0.24 (0.03–1.60)
Stage at diagnosis
 LocalLow71 (45.8)73 (47.1)1.00 (reference)NANANA
High84 (54.2)82 (52.9)1.13 (0.67–1.92)
 RegionalLow24 (42.1)26 (45.6)1.00 (reference)NANANA
High33 (57.9)31 (54.4)1.38 (0.56–3.40)
 DistantLow17 (48.6)22 (62.9)1.00 (reference)NANANA
High18 (51.4)13 (37.1)3.84 (0.50–29.30)
Adenoma size
 <0.55 cmLowNANANA22 (45.8)25 (52.1)1.00 (reference)
High26 (54.2)23 (47.9)1.71 (0.56–5.16)
 ≥ 0.55 cmLowNANANA28 (58.3)29 (60.4)1.00 (reference)
High20 (41.7)19 (39.6)1.53 (0.61–3.80)

NOTE: Matching factors included age, gender, race, and date of blood draw.

Abbreviations: CRC, colorectal cancer; NA, not applicable.

  • aLow versus high based on the median seroreactivity level among all controls combined.

  • bOR and 95% CI adjusted for smoking status, body mass index, and family history of CRC.