Table 2.

Guanylin expression in NAT and tumorsa

Patient characteristicRelative expression NATbRelative expression tumorbLoss (NAT-Tumor)b,cLn (fold change)dPe
Age
 <505.79f (3.86–7.71)−1.80 (−4.02–0.43)7.58g (4.62–10.54)Referent
 50–752.61f (1.94–3.29)−0.29 (−1.00–0.42)2.91g (1.93–3.89)4.67 (1.55–7.80)0.003
 >752.53f (1.56–3.49)−0.27 (−1.26–0.72)2.80g (1.42–4.18)4.79 (1.54–8.03)0.004
Sex
 Male2.95f (2.20–3.70)−0.06 (−0.83–0.72)3.00g (1.92–4.09)Referent
 Female2.71f (1.92–3.51)−0.73 (−1.52–0.07)3.44g (2.32–4.56)0.43 (−1.13–2.00)0.587
T stage
 T1/T23.31f (2.32–4.31)−0.38 (−1.37–0.61)3.69g (2.30–5.09)Referent
 T32.57f (1.83–3.30)−0.55 (−1.28–0.18)3.12g (2.08–4.15)−0.58 (−2.31–1.15)0.512
 T42.86f (1.43–4.29)0.36 (−1.17–1.89)2.49g (0.42–4.58)−1.20 (−3.69–1.29)0.346
Grade
 Well1.240.09 (−1.92–2.10)1.15 (−1.69–3.98)Referent
 Moderate2.77f (2.14–3.39)−0.37 (−0.97–0.25)3.14g (2.26–4.01)1.99 (−0.98–4.96)0.189
 Poor/unknown4.00f (2.54–5.45)−0.47 (−1.95–1.01)4.46g (2.39–6.53)3.32 (−0.20–6.84)0.065
Tumor site
 Left2.41f (0.44–4.37)−2.20 (−4.21 to −0.20)4.61g (1.82–3.69)Referent
 Right2.52f (1.72–3.33)−0.02 (−0.84–0.80)2.54g (1.39–3.69)−2.07 (−5.09–0.95)0.179
 Rectal4.15f (2.58–5.71)−0.54 (−2.28–1.20)4.69g (2.36–7.02)0.08 (−3.58–3.71)0.965
 Sigmoid2.89f (1.96–3.83)−0.40 (−1.30–0.50)3.29g (2.00–4.59)−1.31 (−4.39–1.77)0.402
Node status
 Node negative2.90f (2.28–3.52)−0.56 (−1.18–0.08)3.45g (2.56–4.33)Referent
 Node positive2.64f (1.50–3.77)0.17 (−0.96–1.30)2.46g (0.86–2.82)−0.99 (−2.82–0.85)0.292
  • aGUCA1A expression, normalized to VIL, reflects mean (95% confidence interval).

  • bValues reflect the natural log (Ln) of the GUCA1A/VIL ratio.

  • cValues reflect the difference of the natural log (Ln) of the GUCA1A/VIL ratio in NAT and tumor.

  • dValues reflect the natural log (Ln) of the fold change in GUCA1A/VIL ratio in NAT and tumor.

  • eP reflects the comparison of Ln (fold change) of the given category to the referent category.

  • fExpression is significantly greater than 0.

  • gNAT-tumor (loss) is significantly greater than 0.