Table 4.

Association of baseline mtDNA copy number and subsequent risk of colorectal cancer

mtDNA copy number (tertiles)
3 (Highest)21Ptrenda
Colorectal cancer
 Number of case/control104/475149/473191/475
 OR (95% CI)1.00 (reference)1.26 (0.93–1.70)1.44 (1.06–1.94)
 OR (95% CI)b1.15 (1.02–1.30)0.0204
Colon cancer
 Number of case/control63/45993/454120/469
 OR (95% CI)1.00 (reference)1.27 (0.88–1.83)1.46 (1.02–2.10)
 OR (95% CI)b1.16 (1.01–1.34)0.0430
Rectal cancer
 Number of case/control41/40456/41671/432
 OR (95% CI)1.00 (reference)1.24 (0.80–1.93)1.37 (0.88–2.13)
 OR (95% CI)b1.12 (0.94–1.34)0.2021
Time since blood collection (colorectal cancer)
 <5 years
  Number of case/control40/41061/41276/407
  OR (95% CI)1.00 (reference)1.39 (0.89–2.16)1.59 (1.02–2.48)
  OR (95% CI)b1.12 (0.94–1.33)0.2176
 ≥5 years
  Number of case/control64/46488/449115/459
  OR (95% CI)1.00 (reference)1.18 (0.82–1.70)1.32 (0.92–1.90)
  OR (95% CI)b1.16 (1.00–1.34)0.0463
  • aConditional logistic regression models were used to derive P values for linear trends by modeling the log-transformed mtDNA content as a continuous variable.

  • bOR per SD decrement. Bold indicates significantly significant at P < 0.05.