Table 1.

Selected characteristics of 1,042 epithelial ovarian cancer cases, by relative telomere length z score

CharacteristicQuartile 1 (N = 260)Quartile 2 (N = 261)Quartile 3 (N = 260)Quartile 4 (N = 261)Pb
Age at blood draw, mean (SD)62.2 (10.8)61.5 (10.8)59.7 (11.5)55.7 (12.1)<0.0001
Age at diagnosis, mean (SD)59.8 (10.8)59.1 (10.8)57.4 (11.5)53.3 (12.1)<0.0001
Body mass index 5 years in past (kg/m2), mean (SD)26.4 (5.6)26.7 (10.1)25.8 (5.8)26.2 (8.8)0.62
Smoking status, ever, n (%)124 (50)132 (53)122 (50)113 (47)0.60
Histology, n (%)
 Serous154 (59)156 (60)133 (51)126 (48)
 Mucinous13 (5)17 (7)27 (10)33 (13)
 Endometrioid50 (19)50 (19)59 (23)60 (23)
 Othera43 (17)38 (17)41 (16)42 (16)0.04
Stage, n (%)
 I35 (14)38 (15)52 (20)62 (24)
 II45 (1)48 (18)53 (20)45 (17)
 III137 (53)132 (51)126 (49)115 (44)
 IV42 (16)43 (17)29 (11)38 (15)0.06
Chemotherapy (yes), n (%)119 (87)115 (79)117 (77)101 (69)0.003
BRCA1 mutation, n (%)19 (8)19 (8)12 (5)16 (6)0.53
BRCA2 mutation, n (%)14 (6)12 (5)12 (5)9 (4)0.75

NOTE: N.B, the coefficient of variation (CV) for the average exponentiated T/S ratio of the quality control samples was 14%. For further quality control, we calculated the exponentiated T/S ratio for each sample replicate and excluded samples with a replicate CV of >20% (n = 36).

  • aOther includes the following tumor types: clear cell, mixed histology, epithelial not otherwise specified, and adenocarcinomas.

  • bDifferences between clinical or pathologic characteristics of the subjects by category of telomere length were assessed using the t-statistic or χ2 statistic, as appropriate.