Table 3.

DII from food and supplements and colorectal cancer risk; IWHS, 1986–2010

Cases (n)HRa (95% CI)HRb (95% CI)Cases (n)HRa (95% CI)HRb (95% CI)Cases (n)HRa (95% CI)HRb (95% CI)
Colorectal cancerColon cancerRectal cancer
DII continuous1,6361.09 (1.03–1.14)1.07 (1.01–1.13)1,3291.08 (1.02–1.13)1.05 (0.99–1.12)3251.10 (0.99–1.23)1.11 (0.98–1.25)
DII quintiles
 Quintile 12901 (referent)1 (referent)2361 (referent)1 (referent)581 (referent)1 (referent)
 Quintile 23181.11 (0.94–1.30)1.04 (0.89–1.22)2671.14 (0.96–1.34)1.07 (0.89–1.28)540.93 (0.64–1.35)0.91 (0.62–1.32)
 Quintile 33351.18 (1.01–1.38)1.11 (0.95–1.31)2701.17 (0.98–1.40)1.10 (0.92–1.31)731.28 (0.91–1.81)1.23 (0.86–1.76)
 Quintile 43411.20 (1.03–1.40)1.13 (0.95–1.33)2701.17 (0.98–1.39)1.08 (0.89–1.29)711.24 (0.88–1.76)1.25 (0.87–1.80)
 Quintile 53521.29 (1.10–1.51)1.20 (1.01–1.43)2861.28 (1.08–1.53)1.19 (0.98–1.45)691.25 (0.88–1.77)1.21 (0.81–1.79)
P trend0.0010.030.0080.100.090.16
  • aAge-adjusted.

  • bAdjusted for age, BMI, smoking status, pack-years of smoking, HRT use, education, diabetes, and total energy intake.