Table 2.

mtDNA copy number by selected baseline characteristics of colorectal cancer cases and controls

Cases (n = 444)Controls (n = 1,423)All Participants (n = 1,867)
VariableNo.Geometric mean (95% CI)No.Geometric mean (95% CI)No.Geometric mean (95% CI)
Age
 ≤60 years1940.268 (0.247–0.292)8860.288 (0.280–0.297)1,0800.285 (0.278–0.293)
 >60 years2500.265 (0.248–0.284)5370.293 (0.281–0.305)7870.287 (0.277–0.297)
P0.83550.62760.8538
Postmenopausal
 No1020.271 (0.245–0.300)5490.295 (0.284–0.305)6510.290 (0.280–0.300)
 Yes3420.265 (0.251–0.280)8740.287 (0.280–0.295)1,2160.284 (0.277–0.290)
P0.72390.34530.3730
BMI
 <252630.268 (0.255–0.283)8590.291 (0.285–0.297)1,1220.287 (0.282–0.293)
 ≥251800.263 (0.247–0.280)5640.288 (0.281–0.295)7440.284 (0.278–0.290)
P0.54280.50780.4081
Family history of colorectal cancer
 No4300.268 (0.255–0.280)1,3860.290 (0.286–0.295)1,8160.286 (0.282–0.291)
 Yes140.238 (0.200–0.282)370.278 (0.254–0.304)510.268 (0.248–0.290)
P0.16920.34770.1101
Family history of any cancer
 No3080.269 (0.256–0.283)1,0450.290 (0.285–0.296)1,3530.287 (0.282–0.292)
 Yes1360.259 (0.243–0.277)3780.289 (0.280–0.297)5140.283 (0.276–0.290)
P0.25720.71780.3121
Personal history of inflammatory bowel disease
 No4400.266 (0.254–0.279)1,4140.290 (0.285–0.295)1,8540.286 (0.282–0.290)
 Yes40.305 (0.223–0.415)90.272 (0.226–0.327)130.284 (0.242–0.332)
P0.39270.49290.9174
Personal history of diabetes
 Yes350.258 (0.230–0.290)940.276 (0.260–0.293)1290.273 (0.260–0.288)
 No4090.267 (0.255–0.280)1,3290.291 (0.286–0.296)1,7380.287 (0.283–0.291)
P0.56070.08510.0696
Ever smoked regularly
 Yes110.255 (0.210–0.309)460.301 (0.277–0.326)570.291 (0.270–0.314)
 No4330.267 (0.254–0.280)1,3770.290 (0.285–0.294)1,8100.286 (0.282–0.290)
P0.63710.38130.6148
Ever drank alcohol regularly
 Yes140.302 (0.254–0.359)390.297 (0.272–0.325)530.301 (0.278–0.326)
 No4300.265 (0.253–0.278)1,3840.290 (0.285–0.295)1,8140.285 (0.281–0.290)
P0.13560.58170.1867
Ever exercised regularly
 Yes2090.265 (0.249–0.280)5570.289 (0.282–0.297)7660.285 (0.279–0.292)
 No2350.268 (0.254–0.283)8660.290 (0.285–0.296)1,1010.286 (0.281–0.292)
P0.67380.79210.7800
Ever used aspirin regularly
 Yes110.283 (0.233–0.344)360.286 (0.260–0.314)470.288 (0.265–0.313)
 No4330.266 (0.254–0.279)1,3870.290 (0.285–0.295)1,8200.286 (0.282–0.290)
P0.5360.76100.8678
Ever used hormone replacement therapya
 No3290.268 (0.255–0.282)8370.285 (0.278–0.291)1,1650.281 (0.275–0.288)
 Yes130.311 (0.257–0.376)370.302 (0.275–0.331)500.304 (0.280–0.330)
P0.13130.21440.0657

P values were derived from the two-way ANOVA F test by using log-transformed data.

  • aAmong postmenopausal women.