Table 2.

ORs for receptor-defined cancer associated with grade and age, by racea

BlackWhiteMixed ancestryIndian/AsianOther/unknownInteraction with raceb (P)
OR for ER vs. ER+ breast cancer (95% CI)
Linear trend, per 10 years
All ages0.96 (0.93–1.00)0.84 (0.78–0.90)0.84 (0.78–0.92)0.97 (0.80–1.17)0.88 (0.79–0.99)0.002
<501.01 (0.87–1.16)1.04 (0.74–1.45)0.83 (0.62–1.11)1.09 (0.47–2.52)1.27 (0.84–1.92)0.56
≥500.85 (0.79–0.92)0.67 (0.58–0.76)0.78 (0.67–0.91)0.99 (0.71–1.38)0.74 (0.61–0.92)0.01
Gradec
2 vs. 11.76 (1.36–2.27)2.57 (1.53–4.30)2.09 (1.30–3.336)2.41 (0.65–8.89)1.58 (0.71–3.50)0.70
3 vs. 14.71 (3.63–6.11)8.86 (5.28–14.87)8.49 (5.19–13.84)9.99 (2.58–38.79)4.03 (1.78–9.13)0.07
NK vs. 12.17 (1.68–2.80)3.32 (2.02–5.48)2.52 (1.60–3.98)3.26 (0.92–11.50)1.76 (0.80–3.87)0.59
OR for PR vs. PR+ breast cancer (95% CI)
Linear trend, per 10 years
All ages1.00 (0.97–1.04)0.92 (0.85–0.99)0.92 (0.84–1.00)0.94 (0.77–1.15)0.89 (0.80–0.99)0.06
<501.01 (0.88–1.17)1.01 (0.73–1.41)0.67 (0.48–0.93)0.89 (0.38–2.10)1.06 (0.70–1.61)0.25
≥500.84 (0.78–0.90)0.77 (0.68–0.87)0.85 (0.72–1.00)1.11 (0.80–1.55)0.76 (0.62–0.93)0.27
Gradec
2 vs. 11.18 (0.96–1.46)1.40 (0.95–2.07)1.97 (1.26–3.08)1.78 (0.58–5.42)1.11 (0.55–2.25)0.38
3 vs. 12.91 (2.32–3.64)3.91 (2.59–5.90)4.23 (2.61–6.85)5.10 (1.54–16.73)3.10 (1.46–6.60)0.45
NK vs. 11.45 (1.17–1.80)1.70 (1.16–2.50)1.99 (1.28–3.10)1.88 (0.64–5.52)1.16 (0.57–2.37)0.72
OR for HER2+ vs. HER2 breast cancer (95% CI)
Linear trend, per 10 years
All ages0.87 (0.83–0.91)0.90 (0.82–0.97)1.01 (0.92–1.10)1.01 (0.79–1.29)0.82 (0.71–0.95)0.03
<500.92 (0.78–1.09)1.07 (0.71–1.56)0.92 (0.64–1.31)0.97 (0.37–2.57)0.72 (0.45–1.16)0.79
≥500.82 (0.75–0.90)0.90 (0.78–1.04)1.00 (0.86–1.18)1.50 (0.99–2.29)0.88 (0.67–1.17)0.02
Gradec
2 vs. 11.20 (0.92–1.56)1.52 (0.98–2.37)1.47 (0.91–2.35)1.48 (0.38–5.75)1.35 (0.57–3.24)0.90
3 vs. 11.26 (0.96–1.65)2.02 (1.28–3.20)2.18 (1.33–3.57)2.69 (0.65–11.17)0.95 (0.38–2.42)0.18
NK vs. 11.27 (0.97–1.66)1.72 (1.11–2.66)1.68 (1.06–2.65)2.13 (0.58–7.86)1.02 (0.42–2.49)0.61
  • aContributing numbers for known ER, PR, and HER2, by race, are provided in Table 1.

  • bInteraction of categorical race (black, white, mixed ancestry, Indian/Asian, and Other/NK) with age (linear) or grade (indicator). χ2 test on 4 d.f. Interaction of race with age at all ages is not reported, as age associations differed within each race under and over the age of 50 years.

  • cORs for grade are adjusted for age in 10-year categories.