Table 3.

Age-adjusted and age + laboratory–adjusted ORs for receptor-defined breast cancer associated with race, under and over age 50

Individual receptorsBreast cancer subtypesa
Outcome vs. referenceER vs. ER+PR vs. PR+HER2+ vs. HER2Luminal B vs. luminal AHER2-enriched vs. luminal ATriple-negative vs. luminal A
Number of cases (outcome/reference)
All ages3,199/68483,992/4,6282,083/6,168967/4,062735/4,0621,482/4,062
<501,207/24301,437/1,756848/2,142440/1,433276/1,433526/1,433
≥501,992/4,4182,555/2,8721,235/4,026527/2,629459/2,629956/2,629
OR (95% CI)
Under age 50
Age-adjusted
  Black1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)
  White0.78 (0.63–0.97)0.81 (0.66–1.01)1.07 (0.85–1.35)0.90 (0.66–1.25)0.77 (0.51–1.15)0.92 (0.67–1.25)
  Mixed-ancestry1.08 (0.89–1.32)1.06 (0.85–1.31)0.95 (0.75–1.21)0.79 (0.55–1.14)0.72 (0.45–1.13)1.39 (1.03–1.87)
  Indian/Asian0.87 (0.55–1.38)0.90 (0.56–1.43)0.88 (0.51–1.52)0.74 (0.36–1.56)0.64 (0.25–1.66)0.83 (0.42–1.65)
  Other/unknown1.30 (0.99–1.14)1.48 (1.13–1.18)1.09 (0.79–1.21)1.05 (0.69–1.61)1.22 (0.75–1.98)1.41 (0.96–2.05)
Age + laboratory–adjusted
  Black1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)
  White0.85 (0.67–1.07)0.79 (0.62–0.99)0.94 (0.72–1.22)0.91 (0.64–1.30)0.75 (0.48–1.18)0.98 (0.69–1.38)
  Mixed ancestry1.14 (0.90–1.45)0.92 (0.71–1.19)0.75 (0.56–1.00)0.77 (0.51–1.17)0.62 (0.36–1.05)1.32 (0.92–1.90)
  Indian/Asian0.90 (0.56–1.45)1.08 (0.66–1.78)0.97 (0.54–1.71)1.00 (0.46–2.16)0.68 (0.25–1.80)0.88 (0.43–1.79)
  Other/unknown1.33 (1.01–1.74)1.40 (1.06–1.85)1.07 (0.77–1.47)1.11 (0.72–1.72)1.14 (0.70–1.88)1.36 (0.92–2.00)
Age 50 and over
Age-adjusted
  Black1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)
  White0.67 (0.58–0.77)0.70 (0.61–0.81)1.08 (0.92–1.27)1.00 (0.79–1.26)0.63 (0.48–0.84)0.70 (0.57–0.86)
  Mixed ancestry0.79 (0.67–0.92)0.83 (0.70–0.98)1.31 (1.10–1.56)0.92 (0.69–1.24)1.15 (0.86–1.53)0.86 (0.68–1.08)
  Indian/Asian0.73 (0.54–0.99)0.52 (0.38–0.70)0.76 (0.51–1.13)0.54 (0.29–1.00)0.64 (0.35–1.15)0.63 (0.41–0.97)
  Other/unknown1.04 (0.84–1.30)1.06 (0.85–1.32)0.89 (0.66–1.19)0.75 (0.48–1.17)0.82 (0.53–1.28)0.98 (0.72–1.34)
Age + laboratory–adjusted
  Black1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)
  White0.77 (0.66–0.89)0.72 (0.62–0.83)1.00 (0.83–1.19)1.08 (0.84–1.38)0.67 (0.49–0.92)0.75 (0.60–0.93)
  Mixed ancestry0.91 (0.76–1.09)0.78 (0.64–0.95)1.09 (0.89–1.35)1.00 (0.72–1.40)1.13 (0.80–1.60)0.89 (0.67–1.17)
  Indian/Asian0.84 (0.60–1.16)0.63 (0.45–0.89)0.85 (0.55–1.30)0.88 (0.45–1.70)0.66 (0.35–1.27)0.89 (0.55–1.43)
  Other/unknown1.09 (0.88–1.37)1.03 (0.82–1.29)0.90 (0.67–1.22)0.81 (0.52–1.26)0.85 (0.54–1.33)1.00 (0.73–1.37)
  • aSubtypes defined immunohistochemically: luminal A (ER+/PR+HER2), luminal B (ER+/PR+HER2+), HER2-enriched (ERPRHER2+), and triple-negative (ERPRHER2). ORs adjusted for age as a linear term and laboratory as an indicator variable.