Cumulative incidence of breast cancer in BRCA1/2 carriers, excluding index cases, in the study population (Northern Netherlands) and reference population (rest of the Netherlands)
| BRCA1 carriers | BRCA2 carriers | |||
|---|---|---|---|---|
| Age, y | Northern Netherlands | Rest of the Netherlands | Northern Netherlands | Rest of the Netherlands |
| Crude risks | N = 467 | N = 1,091 | N = 269 | N = 305 |
| ≤30 | 2.8 (1.5–4.7) | 3.7 (2.6–5.0) | 0.4 (0.0–2.2) | 0.7 (0.1–2.3) |
| ≤40 | 16.0 (12.4–20.0) | 23.1 (20.2–26.1) | 7.3 (4.3–11.4) | 13.3 (9.3–17.9) |
| ≤50 | 37.8 (31.9–43.6) | 46.6 (42.5–50.6) | 28.2 (21.3–35.6) | 37.6 (30.4–44.7) |
| ≤60 | 50.1 (43.2–56.7) | 61.1 (56.0–65.7) | 46.3 (36.5–55.6) | 54.8 (45.9–62.9) |
| ≤70 | 58.4 (50.2–65.7) | 67.9 (61.7–73.2) | 63.9 (50.3–74.7) | 60.6 (50.2–69.4) |
| ≤75 | 61.2 (51.5–69.4) | 71.0 (63.8–77.1) | 68.4 (52.7–79.8) | — |
| Weighted risks | N = 467 | N = 913 | N = 269 | N = 229 |
| ≤30 | 1.9 (0.8–4.4) | 2.7 (1.4–5.4) | 0.3 (0.0–6.4) | 0.2(0.0–2.0) |
| ≤40 | 11.8 (8.4–16.4) | 17.0 (12.9–22.2) | 7.6 (4.1–13.8) | 9.5 (4.8–18.2) |
| ≤50 | 32.3 (26.4–39.0) | 36.0 (30.0–42.7) | 29.0 (21.3–38.6) | 29.9 (20.6–42.1) |
| ≤60 | 46.8 (39.8–54.4) | 49.9 (42.7–57.5) | 46.8 (36.8–58.1) | 49.1 (37.5–62.1) |
| ≤70 | 52.8 (45.1–61.0) | 54.6 (46.9–62.7) | 66.2 (54.2–77.7) | 63.7 (50.6–76.6) |
| ≤75 | 54.2 (46.2–62.7) | 58.6 (50.2–67.2) | 68.2 (55.8–80.0) | — |
NOTE: Estimation of the crude risk and risk weighted to an equal contribution from the different birth cohorts and OCCR regions in each population (weighted risks).