Table 5.

Associations of the components of WCRF/AICR index score and prostate cancer risk by cancer stagea

Overall prostate cancerLocalizedLocally advancedLocally advanced vs. localized
ScoreControl, nNOR (95% CI)PtrenddnOR (95% CI)PtrendnOR (95% CI)PtrendOR (95% CI)Ptrend
Body fatness
 0–0.255,007747167916511
 0.52,9284481.02 (0.90–1.16)3900.97 (0.84–1.10)521.37 (0.95–1.99)1.38 (0.93–2.05)
 0.751,9982930.96 (0.83–1.11)2640.95 (0.81–1.10)291.16 (0.74–1.81)1.18 (0.73–1.90)
 12,0723181.00 (0.87–1.16)2790.96 (0.82–1.11)381.48 (0.98–2.24)1.58 (1.01–2.45)
 Dose responseb1.01 (0.97–1.05)0.731.00 (0.96–1.04)0.851.11 (0.99–1.24)0.081.11 (0.99–1.26)0.08
Physical activity
 04,796688160218011
 0.53,9566101.08 (0.96–1.21)5591.13 (1.00–1.28)470.71 (0.49–1.03)0.62 (0.42–0.93)
 13,2535081.10 (0.97–1.24)4511.11 (0.97–1.27)571.03 (0.72–1.46)0.96 (0.65–1.41)
 Dose responsec1.05 (0.98–1.12)0.141.06 (0.99–1.13)0.091.00 (0.83–1.20)0.960.96 (0.79–1.18)0.71
Foods and drinks that promote weight gain
 0–0.252,948438138615111
 0.54,0056071.01 (0.88–1.15)5451.03 (0.90–1.19)600.85 (0.58–1.24)0.79 (0.52–1.20)
 0.753,8906061.04 (0.91–1.20)5451.07 (0.92–1.23)540.79 (0.53–1.17)0.75 (0.49–1.15)
 11,1621550.91 (0.74–1.12)1360.91 (0.73–1.12)191.02 (0.58–1.78)1.06 (0.58–1.95)
 Dose responseb1.00 (0.95–1.06)0.961.00 (0.95–1.06)0.970.99 (0.85–1.15)0.860.98 (0.83–1.16)0.81
Plant foods
 0–0.251,063165114511811
 0.52,4563981.04 (0.85–1.27)3551.04 (0.84–1.28)411.06 (0.60–1.87)0.99 (0.54–1.83)
 0.752,5474031.00 (0.82–1.22)3570.99 (0.80–1.22)441.10 (0.62–1.95)1.02 (0.55–1.90)
 15,9398400.87 (0.72–1.06)7550.87 (0.71–1.06)810.88 (0.51–1.54)0.95 (0.52–1.74)
 Dose responseb0.94 (0.89–0.99)0.020.94 (0.89–0.99)0.020.94 (0.81–1.09)0.450.98 (0.83–1.15)0.81
Animal foods
 08,2771,23011,094113011
 0.53,1295111.09 (0.97–1.22)4581.10 (0.98–1.24)501.01 (0.72–1.42)0.94 (0.65–1.35)
 1599650.73 (0.56–0.96)600.76 (0.58–1.01)40.43 (0.16–1.19)0.61 (0.22–1.74)
 Dose responsec0.98 (0.89–1.07)0.610.99 (0.90–1.09)0.840.86 (0.65–1.14)0.280.88 (0.65–1.20)0.43
Alcohol
 03,745559150015511
 0.51,7882590.97 (0.83–1.14)2320.96 (0.82–1.14)261.02 (0.64–1.65)1.16 (0.70–1.94)
 16,47281.00 (0.90–1.13)8801.00 (0.88–1.12)1031.10 (0.78–1.55)1.12 (0.77–1.62)
 Dose responsec1.00 (0.95–1.06)0.891.00 (0.94–1.06)0.981.05 (0.89–1.25)0.581.05 (0.88–1.26)0.58
  • aAdjusted for age (continuous variable), recruitment center, family history of prostate cancer, smoking status, and total energy intake (kcal/day). All components were mutually adjusted for each other except for the “foods and drinks that promote weight gain” component.

  • bORs/RRRs and 95% CIs per 0.25 score increment.

  • cORs/RRRs and 95% CIs per 0.5 score increment.

  • dPtrend were calculated by modeling components of WCRF/AICR score as a continuous variable.