Table 5.

Combined effects of WHtR and blood glucose level on risk of obesity-related cancers

WHtR/blood glucoseaLow WHtRb/Nl glucoseLow WHtRb/Abnl glucoseHigh WHtRb/Nl glucoseHigh WHtRb/Abnl glucose
All subjects
N1,3121801,955316
 Person-years112/22,76712/2,755230/34,54831/4,231
 IR/10,000 person-years49.243.566.673.3
 HR (95% CI)
  Unadjusted1.0 (reference)0.94 (0.52–1.7)1.3 (1.1–1.7)1.6 (1.1–2.4)
  Adjusted model 1c1.0 (reference)0.97 (0.53–1.8)1.5 (1.2–2.0)2.1 (1.4–3.2)
  Adjusted model 2d1.0 (reference)0.97 (0.53–1.8)1.5 (1.1–2.0)2.0 (1.3–3.2)
Males
 Cancers/person-years18/6,9742/1,04373/15,28112/2,470
 IR/10,000 person-years25.819.247.848.6
 HR (95% CI)
  Unadjusted1.0 (reference)0.79 (0.18–3.4)1.8 (1.1–3.0)2.1 (1.0–4.4)
  Adjusted model 1c1.0 (reference)0.76 (0.18–3.3)1.9 (1.1–3.2)2.3 (1.1–4.8)
  Adjusted model 2d1.0 (reference)0.76 (0.18–3.3)1.7 (0.92–3.0)1.9 (0.85–4.4)
Females
 Cancers/person-years94/15,79310/1,713157/19,26719/1,760
 IR/10,000 person-years59.558.481.5107.9
 HR (95% CI)
  Unadjusted1.0 (reference)1.0 (0.53–2.0)1.3 (1.0–1.7)1.9 (1.2–3.2)
  Adjusted model 1c1.0 (reference)1.0 (0.52–1.9)1.5 (1.1–1.9)2.3 (1.4–3.8)
  Adjusted model 2d1.0 (reference)1.0 (0.52–1.9)1.5 (1.1–2.0)2.2 (1.3–3.9)

Abbreviations: Abnl, abnormal; IR, incidence rate; Nl, normal.

  • aNl versus Abnl glucose: <125 (not on insulin or oral hypoglycemics) versus ≥125 mg/dL or treated.

  • bLow versus high WHtR: <0.51 versus ≥0.51 for men; <0.57 versus ≥0.57 for women.

  • cModel 1: adjusted for age, sex (in all-subjects models), height, education level, alcohol intake, cigarettes/day, and physical activity.

  • dModel 2: model 1 plus BMI.