Table 2.

Effect of BMI and waist size on risk of obesity-related cancers in men and women

BMI (kg/m2)Lean (<25)Overweight (25–<30)Obese (≥30)
All subjects
 Number1,5281,647588
 Cancer cases/person-yearsa130/26,699185/28,46370/9,140
 IR/10,000 person-years48.765.076.6
 HR (95% CI)
  Unadjusted1.0 (reference)1.3 (1.1–1.7)1.7 (1.2–2.2)
  Adjustedb1.0 (reference)1.5 (1.2–1.9)1.7 (1.3–2.3)
Males
 Cancer cases/person-yearsa22/8,74867/13,96116/3,060
 IR/10,000 person-years25.148.052.3
 HR (95% CI)
  Unadjusted1.0 (reference)1.9 (1.2–3.1)2.3 (1.2–4.4)
  Adjustedb1.0 (reference)1.9 (1.2–3.1)2.3 (1.2–4.4)
Females
 Cancer cases/person-yearsa108/17,951118/14,50254/6,081
 IR/10,000 person-years60.281.488.8
 HR (95% CI)
  Unadjusted1.0 (reference)1.4 (1.0–1.8)1.5 (1.1–2.1)
  Adjustedb1.0 (reference)1.4 (1.1–1.8)1.6 (1.2–2.3)
WAIST (cm)<84 (m), <81 (f)84–<94 (m), 81–<91 (f)≥94 (m), ≥91 (f)
All subjects
 Number5171,5671,679
 Cancer cases/person-yearsa31/8,166135/27,520219/28,616
 IR/10,000 person-years38.049.176.5
 HR (95% CI)
  Unadjusted1.0 (reference)1.2 (0.84–1.8)1.9 (1.3–2.8)
  Adjustedb1.0 (reference)1.2 (0.79–1.7)1.8 (1.2–2.6)
Males
 Cancer cases/person-yearsa6/4,35241/11,78658/9,630
 IR/10,000 person-years13.834.860.2
 HR (95% CI)
  Unadjusted1.0 (reference)2.4 (1.0–5.7)4.4 (1.9–10.1)
  Adjustedb1.0 (reference)2.2 (0.93–5.2)3.9 (1.7–9.1)
Females
 Cancer cases/person-yearsa25/3,81594/15,733161/18,986
 IR/10,000 person-years65.559.784.8
 HR (95% CI)
  Unadjusted1.0 (reference)0.88 (0.57–1.4)1.3 (0.82–1.9)
  Adjustedb1.0 (reference)0.89 (0.57–1.4)1.3 (0.86–2.0)

Abbreviation: IR, incidence rate.

  • aFollow-up time begins 4 years after end of exposure period.

  • bAdjusted for age, sex (in all-subjects models), height, education, alcohol, cigarettes/day, and physical activity.