Table 2.

Fecal immunochemical test result according to neoplastic lesions detected in the subjects included

Fecal Hb threshold 100 ng/mLFecal Hb threshold 50 ng/mL
Colorectal lesiona<100 (413)≥100 (61)OR (95% CI)P value<50 (403)≥50 (71)OR (95% CI)P value
Advanced adenomab
 Present (145)100 (69%)45 (31%)8.8 (4.7–16.2)<0.00194 (64.8%)51 (35.2%)8.4 (4.8–14.8)<0.001
 Absent (329)313 (95.1%)16 (4.9%)1309 (93.9%)20 (6.1%)1
Location of adenomas
 Distal to splenic flexure (357)299 (83.8%)58 (16.2%)7.3 (2.2–23.9)<0.001291 (81.2%)67 (18.8%)6.4 (2.3–18.2)<0.001
 Only proximal to splenic flexure (116)113 (97.4%)3 (2.6%)1112 (96.6%)4 (3.4%)1
Location of advanced adenomas
 Distal to splenic flexure (109)67 (61.5%)42 (38.5%)6.7 (1.9–8.8)0.00164 (58.7%)45 (41.3%)3.4 (1.3–8.8)0.014
 Only proximal to splenic flexure (35)32 (91.4%)3 (8.6%)129 (82.9%)6 (17.1%)1
European classificationc
 High risk (49)27 (55.1%)22 (44.9%)20.1(8.8–45.8)<0.00126 (53.1%)23 (46.9%)16.9 (7.8–36.9)<0.001
 Intermediate risk (143)115 (80.4%)28 (19.6%)6 (2.9–12.4)109 (76.2%)34 (23.8%)5.9 (3.1–11.5)
 Low risk (282)271 (96.1%)11 (3.9%)1268 (95%)14 (5%)1
Adenoma's morphologyd
 Flat (any) (149)138 (92.6%)11 (7.4%)0.4 (0.2–0.9)0.01132 (88.6%)17 (11.4%)0.6 (0.3–1.1)0.1
 Flat (no) (325)275 (84.6%)50 (15.4%)1271 (83.4%)54 (16.6%)1
 Sessile (any) (279)248 (88.9%)31 (11.1%)0.7 (0.4–1.2)0.1241 (86.4%)38 (13.6%)0.7 (0.4–1.3)0.3
 Sessile (no) (195)165 (84.6%)30 (15.4%)1162 (83.1%)33 (16.9%)1
 Pedunculated (any) (144)98 (68.1%)46 (31.9%)9.8 (5.2–18.4)<0.00195 (66%)49 (34%)7.2 (4.1–12.5)<0.001
 Pedunculated (no) (330)315 (95.4%)15 (4.6%)1308 (93.3%)22 (6.7%)1

NOTE: Qualitative variables are expressed as absolute numbers and percentage. Differences were analyzed with χ2 test. Differences with P < 0.05 are considered statistically significant.

  • aIndividuals were classified according to the most advanced lesion.

  • bAdvanced adenoma: adenoma >1 cm in size or with high-grade dysplasia or intramucosal carcinoma or with villous component (>20%).

  • cLow risk, ≤2 non-advanced adenomas; intermediate risk, 3 and 4 adenomas, 10 to 20 mm in size, <10 mm advanced adenomas; high risk, ≥5 adenomas or ≥20 mm in size.

  • dAdenoma's morphology according to Paris classification.