Table 3.

Prevalence and distribution of HPV genotypes in cervical lesions, by age

A. Women ages 15 to 26 years (protocols 013 and 015), N = 8,798
CIN1a (no. of lesions = 1,366), n (%)CIN2a (no. of lesions = 456), n (%)CIN3a (no. of lesions = 393), n (%)AISa (no. of lesions = 19), n (%)
HPV typeMin.bProp.AnycMin.bProp.AnycMin.bProp.AnycMin.bProp.Anyc
634 (2)45 (3)77 (6)1 (0.2)1 (0.3)12 (3)2 (1)3 (0.7)16 (4)0 (0)1 (5)0 (0)
1114 (1)16 (1)30 (2)0 (0)0 (0)5 (1)1 (0.3)1 (0.3)4 (1)0 (0)0 (0)0 (0)
16138 (10)230 (17)294 (22)107 (23)154 (34)168 (37)130 (33)216 (55)225 (57)8 (42)14 (75)15 (79)
1828 (2)48 (4)110 (8)12 (3)20 (4)44 (10)5 (1)8 (2)29 (7)2 (11)4 (20)7 (37)
3165 (5)106 (8)166 (12)39 (9)58 (13)76 (17)30 (8)47 (12)67 (17)0 (0)0 (0)0 (0)
3327 (2)36 (3)78 (6)15 (3)23 (5)36 (8)16 (4)28 (7)47 (12)0 (0)0 (0)1 (5)
3523 (2)30 (2)51 (4)13 (3)16 (4)23 (5)5 (1)6 (2)10 (3)0 (0)0 (0)0 (0)
3948 (4)67 (5)107 (8)5 (1)8 (2)22 (5)1 (0.3)2 (1)17 (4)0 (0)0 (0)1 (5)
4515 (1)20 (1)53 (4)0 (0)0 (0)16 (4)2 (1)0 (0)21 (5)0 (0)0 (0)1 (5)
5177 (6)132 (10)195 (14)17 (4)29 (6)54 (12)3 (1)5 (1)29 (7)0 (0)0 (0)2 (11)
5255 (4)91 (7)156 (11)27 (6)48 (11)73 (16)14 (4)29 (7)59 (15)0 (0)0 (0)4 (21)
5691 (7)155 (11)217 (16)4 (1)5 (1)27 (6)2 (0.5)3 (0.9)31 (8)0 (0)0 (0)1 (5)
5860 (4)89 (7)135 (10)24 (5)34 (7)49 (11)13 (3)22 (6)36 (9)0 (0)0 (0)1 (5)
5922 (2)30 (2)61 (4)3 (1)4 (1)15 (3)0 (0)0 (0)9 (2)0 (0)0 (0)0 (0)
B. Women ages 24 to 45 years (protocol 019), N = 1,858
CIN1d (no. of lesions = 172), n (%)CIN2d (no. of lesions = 41), n (%)CIN3d (no. of lesions = 55), n (%)AISd (no. of lesions = 5), n (%)
HPV typeMin.bProp.AnycMin.bProp.AnycMin.bProp.AnycMin.bProp.Anyc
62 (1)3 (2)7 (4)0 (0)0 (0)3 (7)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)
112 (1)3 (2)4 (2)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)
1623 (13)30 (17)34 (20)10 (24)16 (39)17 (41)26 (47)32 (58)33 (60)3 (60)5 (100)5 (100)
184 (2)4 (2)4 (2)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)
313 (2)4 (2)5 (3)3 (7)3 (8)4 (10)6 (11)7 (12)8 (15)0 (0)0 (0)1 (20)
333 (2)4 (2)5 (3)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)
354 (2)4 (2)5 (3)0 (0)0 (0)0 (0)0 (0)0 (0)1 (2)0 (0)0 (0)0 (0)
391 (1)1 (0.8)5 (3)1 (2)1 (2)1 (2)1 (2)1 (2)1 (2)0 (0)0 (0)0 (0)
455 (3)7 (4)9 (5)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)
518 (5)13 (8)19 (11)1 (2)1 (3)2 (5)1 (2)1 (2)3 (5)0 (0)0 (0)0 (0)
528 (5)14 (8)20 (12)5 (12)6 (14)7 (17)7 (13)8 (15)11 (20)0 (0)0 (0)1 (20)
5615 (9)20 (12)24 (14)1 (2)1 (3)4 (10)0 (0)0 (0)1 (2)0 (0)0 (0)0 (0)
589 (5)12 (7)16 (9)3 (7)4 (10)4 (10)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)
599 (5)6 (3)9 (5)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)

NOTE: A subject is counted only once within each applicable row, but may appear in more than one row.

  • aOf the 1,366 CIN1 lesions, 697 had a single-type infection, 416 had >1 HPV type, 246 were negative to all 14 tested types, and 7 had missing data. Of the 456 CIN2 lesions, 267 had a single-type infection, 139 had >1 HPV type, 47 were negative to all 14 tested types, and 3 had missing data. Of the 393 CIN3 lesions, 224 had a single-type infection, 149 had >1 HPV type, 19 were negative to all 14 tested types, and 1 had missing data. Of the 19 AIS lesions, 10 had a single-type infection, 8 had >1 HPV type, and 1 was negative to all 14 tested types.

  • bMinimum estimate of attribution. Each lesion is counted only once within the row.

  • cAttribution irrespective of coinfection. Each lesion is counted only once within the row.

  • dOf the 172 CIN1 lesions, 92 had a single-type infection, 33 had >1 HPV type, 45 were negative to all 14 tested types, and 2 had missing data. Of the 41 CIN2 lesions, 24 had a single-type infection, 8 had >1 HPV type, 7 were negative to all 14 tested types, and 2 had missing data. Of the 55 CIN3 lesions, 41 had a single-type infection, 8 had >1 HPV type, 5 were negative to all 14 tested types, and 1 had missing data. Of the 5 AIS lesions, 3 had a single-type infection, 2 had >1 HPV type, and 0 were negative to all 14 tested types.