Table 4.

Associations of WCRF/AICR index score with prostate cancer risk

WCRF/AICR index score
0–2>2 to <33 to <44–6Dose response (per 1 unit score)Ptrendd
Controls, n1,9833,1784,6582,186
Overall cases, n294479688345
 Model 1a11.02 (0.87–1.19)0.99 (0.85–1.14)1.05 (0.88–1.24)
 Model 211.01 (0.86–1.18)0.96 (0.83–1.11)1.01 (0.85–1.19)0.99 (0.94–1.05)0.71
Localized casesb, n257429626300
 Model 111.04 (0.88–1.22)1.02 (0.87–1.19)1.04 (0.87–1.24)
 Model 211.02 (0.87–1.21)0.99 (0.84–1.16)0.99 (0.83–1.19)0.99 (0.93–1.05)0.72
Locally advanced casesb, n34485943
 Model 110.90 (0.57–1.40)0.73 (0.47–1.12)1.13 (0.71–1.78)
 Model 210.90 (0.57–1.40)0.73 (0.48–1.13)1.16 (0.72–1.84)1.00 (0.85–1.18)0.97
Locally advanced vs. localizedc, n34/25748/42959/62643/300
 Model 110.86 (0.54–1.38)0.70 (0.44–1.09)1.06 (0.65–1.73)
 Model 210.87 (0.54–1.41)0.75 (0.47–1.19)1.17 (0.71–1.94)1.02 (0.86–1.22)0.81
Low-grade casesb, n188331465220
 Model 111.10 (0.91–1.33)1.06 (0.89–1.27)1.07 (0.87–1.32)
 Model 211.08 (0.90–1.31)1.02 (0.85–1.22)1.00 (0.81–1.24)1.00 (0.93–1.07)0.93
High-grade casesb, n106146220124
 Model 110.84 (0.65–1.09)0.83 (0.66–1.06)0.99 (0.75–1.29)
 Model 210.85 (0.66–1.10)0.84 (0.66–1.07)1.00 (0.76–1.31)0.97 (0.89–1.07)0.55
High vs. low gradec, n106/188146/331220/465124/220
 Model 110.76 (0.55–1.03)0.79 (0.59–1.05)0.93 (0.67–1.30)
 Model 210.74 (0.54–1.01)0.79 (0.58–1.06)0.96 (0.68–1.34)0.97 (0.87–1.09)0.61

NOTE: Model 1 for cancer subtypes: adjusted for age (continuous variable) and recruitment center; and Model 2: adjusted for family history of prostate cancer, smoking status, and total energy intake (continuous variable). For definitions of localized, locally advanced, and low- and high-grade cancer, please refer to Materials and Methods.

  • aORs and 95% CIs from conditional logistic regression, matched by 5-year age band and recruitment center, and adjusted by age (continuous variable).

  • bRRRs and 95% CIs from multinomial logistic regression.

  • cRRRs and 95% CIs from logistic regression.

  • dPtrend for the association of prostate cancer risk per 1 unit increment in index score.