Table 3.

Age-adjusted and multivariable-adjusted HRs for colorectal cancer–specific and all-cause death according to the intake of dairy products

Colorectal cancer–specific deathAll-cause death
Age adjustedMultivariableaMultivariablea,bAge adjustedMultivariableaMultivariablea,b
Dairy productsDaily intake (g/day)CasesColorectal cancer–specific deathsHR (95% CI)HR (95% CI)HR (95% CI)Total deathsHR (95% CI)HR (95% CI)HR (95% CI)
Total
 Quartile 1<150964245ref.ref.ref.369ref.ref.ref.
 Quartile 2150–2759672390.94 (0.78–1.13)0.94 (0.78–1.13)0.96 (0.80–1.16)3590.93 (0.80–1.09)0.95 (0.81–1.10)0.98 (0.84–1.14)
 Quartile 3276–4529632550.89 (0.74–1.08)0.90 (0.75–1.09)0.97 (0.80–1.18)3870.90 (0.78–1.05)0.93 (0.79–1.08)0.99 (0.84–1.16)
 Quartile 4>4529652891.02 (0.85–1.23)1.05 (0.86–1.27)1.17 (0.96–1.43)4100.99 (0.85–1.15)1.02 (0.87–1.20)1.16 (0.98–1.36)
P trend0.680.490.060.950.620.05
 Per 100 g/day1.00 (0.97–1.03)1.00 (0.98–1.03)1.02 (0.99–1.05)1.00 (0.98–1.02)1.00 (0.98–1.02)1.02 (0.99–1.04)
Milk
 Quartile 1<24965220ref.ref.ref.351ref.ref.ref.
 Quartile 224–1479702561.01 (0.84–1.22)1.01 (0.84–1.22)1.03 (0.85–1.25)3731.02 (0.88–1.19)1.03 (0.88–1.20)1.05 (0.90–1.23)
 Quartile 3148–2939932640.91 (0.75–1.11)0.91 (0.75–1.11)0.99 (0.81–1.20)3940.97 (0.83–1.13)0.97 (0.83–1.14)1.04 (0.89–1.22)
 Quartile 4>2939312881.07 (0.88–1.29)1.08 (0.89–1.32)1.21 (0.99–1.48)4071.07 (0.91–1.25)1.09 (0.93–1.28)1.21 (1.03–1.43)
P trend0.480.400.050.450.320.09
 Per 100 g/day1.01 (0.98–1.04)1.01 (0.98–1.04)1.02 (0.99–1.05)1.01 (0.98–1.03)1.01 (0.98–1.03)1.02 (0.99–1.05)
Yoghurt
 Quartile 1<2936245ref.ref.ref.380ref.ref.ref.
 Quartile 22–249932620.96 (0.78–1.18)0.95 (0.78–1.17)1.06 (0.86–1.31)3740.91 (0.77–1.07)0.91 (0.77–1.08)1.01 (0.85–1.20)
 Quartile 325–899652731.06 (0.88–1.28)1.06 (0.87–1.29)1.15 (0.94–1.40)4001.03 (0.89–1.21)1.06 (0.91–1.24)1.13 (0.96–1.33)
 Quartile 4>899652480.98 (0.80–1.19)1.00 (0.81–1.22)1.09 (0.88–1.34)3710.94 (0.80–1.10)0.98 (0.83–1.15)1.08 (0.92–1.28)
P trend0.960.830.590.820.740.34
 Per 50 g/day0.99 (0.95–1.03)0.99 (0.96–1.03)1.01 (0.97–1.04)0.98 (0.95–1.01)0.99 (0.96–1.02)1.01 (0.98–1.04)
Cheese
 Quartile 1<15943270ref.ref.ref.416ref.ref.ref.
 Quartile 215–259852770.93 (0.78–1.10)0.93 (0.78–1.11)0.97 (0.81–1.16)4010.84 (0.73–0.97)0.85 (0.74–0.98)0.90 (0.78–1.04)
 Quartile 326–499662360.91 (0.75–1.10)0.92 (0.76–1.12)0.93 (0.77–1.14)3580.87 (0.75–1.01)0.88 (0.75–1.03)0.92 (0.79–1.08)
 Quartile 4>499652450.89 (0.73–1.08)0.91 (0.74–1.12)0.93 (0.76–1.14)3500.83 (0.71–0.98)0.85 (0.72–1.00)0.87 (0.74–1.04)
P trend0.300.440.480.070.120.19
 Per 25 g/day0.97 (0.92–1.01)0.97 (0.91–1.04)0.98 (0.92–1.05)0.97 (0.92–1.01)0.97 (0.92–1.02)0.98 (0.93–1.03)
  • aStratified by center and adjusted for age at colorectal cancer diagnosis (continuously per one year increase), sex, prediagnostic BMI (continuous), smoking status (never, former, current, unknown), and energy intake (continuous).

  • bAdditionally adjusted for tumor subsite (colon and rectum), disease stage (I, II, III, IV, unknown, unavailable for center), and differentiation grade (well, moderately, poorly, unknown, unavailable for center).