Table 2.

Mean urinary (+SD) levels of 10 biomarkers assessed by ELISA in cohort of 320 subjects

Total bladder cancerLow-grade bladder cancerHigh-grade bladder cancerNMIBCMIBCTotal controls
(57.2%)(24.1%)(30.6%)(87.4%)(12.6%)(42.8%)
n = 183n = 77n = 98n = 153n = 22n = 137
IL8 (pg/mL)a,b,c599 ± 1,765269 ± 1,260877 ± 2,095461 ± 1,5361,644 ± 2,903300 ± 1,355
MMP9 (ng/mL)b,c15.4 ± 65.64.86 ± 13.724.2 ± 88.09.79 ± 31.556.9 ± 16729.7 ± 154
SERPINA1 (ng/mL)a,b,c26.1 ± 10021.2 ± 10530.8 ± 10121.8 ± 96.359.6 ± 1353.76 ± 22.3
ANG (pg/mL)a,b460 ± 766300 ± 616608 ± 867432 ± 731752 ± 1,037293 ± 633
VEGFA (pg/mL)a,b623 ± 669532 ± 681710 ± 670583 ± 606969 ± 1,014345 ± 322
CA9 (pg/mL)a,b,c103 ± 56251.5 ± 171150 ± 75291.5 ± 583212 ± 5137.02 ± 42.6
MMP10 (pg/mL)a,b21.6 ± 18736.2 ± 28611.6 ± 34.825.0 ± 2044.53 ± 13.66.96 ± 46.3
APOE (pg/mL)a0.011 ± 0.0490.005 ± 0.0170.013 ± 0.0570.007 ± 0.0200.029 ± 0.110.003 ± 0.007
SERPINE1 (ng/mL)a,b,c3,866 ± 10,5181,773 ± 4,2235,621 ± 13,6263,478 ± 10,5897,061 ± 11,3652,487 ± 6,713
SDC1 (pg/mL)a,c141 ± 86962.9 ± 57.9207 ± 1,185143 ± 948146 ± 17137.0 ± 54.0
  • aP < 0.05 comparing total bladder cancer to total controls.

  • bP < 0.05 comparing low-grade bladder cancer to high-grade bladder cancer.

  • cP < 0.05 comparing NMIBC to MIBC.