Table 4.

The association between the breast cancer SNPs and percent density stratified by selected nongenetic variables among Norwegian postmenopausal women (N = 2,348)

BMI (kg/m2)aParityaEPT useaAlcohol usea
<25≥25NulliparousParousNeverPastCurrentUsersNonusers
n = 1,303n = 1,045n = 215n = 2,119n = 1,318n = 692n = 269n = 2,028n = 299
LocusSNPAllelesBetabPinteractionBetaPinteractionBetaPinteractionBetaPinteraction
6q25.1rs9383938G/T2.131.200.30265.621.970.14750.974.07−0.190.54592.300.510.6016
TXNRD2rs8141691A/C−0.77−2.160.27020.25−1.450.4471−1.90−0.85−0.190.3951−1.54−0.520.8190
2q35rs1338704A/G0.880.090.1603−0.310.670.88870.850.060.040.33970.68−0.390.8783
6q25.1rs3734805A/C2.00−0.160.05885.030.800.02250.860.004.760.54920.812.310.8067
10q26.13rs1051010A/T−0.84−0.040.34500.16−0.650.5924−0.13−1.37−1.010.3567−0.791.580.7477
SLC4A7rs4973768C/T0.89−0.020.3978−2.080.760.16280.44−0.291.990.49800.431.310.6346
9q31.2rs865686G/T1.43−0.670.01050.060.470.84790.59−0.101.010.92080.47−0.080.8257
TGFB1rs1800470C/T−0.17−0.570.5220−0.23−0.370.9188−0.20−0.550.690.7580−0.450.900.6592
1p11.2rs1124943C/T0.530.030.5633−0.510.420.64710.050.670.830.39060.350.920.5300
8q24.21rs1328161A/G0.530.030.563−0.510.420.64710,050,670,830,39060,350,920,5300
MRPS30:FGF10rs4415084A/G−1.501.010.0051−1.15−0.360.7589−1,000,790,470,1042−0,39−0,900,4273
COX11rs6504950A/G0.23−1.000.28043.24−0.520.3319−0.58−0.68−0.440.7980−0.541.230.3283
CASP8rs1746827C/T0.380.220.8554−1.130.520.49961.36−0.59−0.160.19800.350.310.4842
MRPS30:FGF10rs1094167A/G−0.14−0.250.7742−0.04−0.260.5640−0.26−0.351.930.2003−0.230.210.6336
MAP3K1rs889312A/C−0.510.110.4119−2.10−0.090.0883−0.560.62−0.810.57800.02−2.100.5520
LSP1rs3817198T/C0.110.200.7383−0.040.120.6409−0.050.411.190.5885−0.011.370.2054
TOX3rs3803662C/T−0.07−0.210.5095−1.070.210.5126−0.43−0.241.320.25270.24−1.110.3553

NOTE: Bold indicates P values <0.05.

  • aAs ascertained at the time of mammography.

  • bFor each SNP the beta coefficient represents the change (on an arithmetic scale) in percent MD associated with each copy of the minor allele after adjustment for age, BMI, and study assuming an additive model of inheritance.