Table 4.

G × E interactions with nominal interaction P value <0.01

SNP/chromosomal location environmental variableGene/locusORa,bCINominal P valueAdjusted P valuePhet
rs6691170/1q41DUSP101.221.08–1.391.74 × 10−30.300.18
PMH use at reference (yes/no)
rs3217810/12p13.32cCCND20.770.65–0.912.98 × 10−30.450.20
Dietary fiber (per 10 g/d)
rs3217810/12p13.32cCCND20.600.42–0.854.11 × 10−30.560.12
Dietary folate (per 500 mcg/d)
rs7136702/12q13.13cLARP4/DIP2B1.281.07–1.547.39 × 10−30.770.68
Vegetable consumption (per 5 servings/day)
rs10936599/3q26.2MYNN0.860.77–0.967.73 × 10−30.780.31
Sex (female/male)
rs719725/9p24cTPD52L3/IL-33/UHRF2/GLDC1.101.02–1.199.59 × 10−30.860.90
Fruit consumption (high vs. low)
  • aInteraction OR for SNP (log-additive for number of risk alleles) × exposure (as categorized above).

  • bAdjusted for age, sex, study center, and population substructure (principal components 1–3).

  • cAnalyses further adjusted for energy intake (where available).