Table 4.

Age-adjusted and multivariable-adjusted HRs for colorectal cancer–specific and all-cause death according to the intake of dietary calcium

Colorectal cancer–specific deathAll-cause death
Age adjustedMultivariableaMultivariablea,bAge adjustedMultivariableaMultivariablea,b
Dietary calciumDaily intake (mg/day)CasesColorectal cancer–specific deathsHR (95% CI)HR (95% CI)HR (95% CI)Total deathsHR (95% CI)HR (95% CI)HR (95% CI)
Total
 Quartile 1<699963249ref.ref.ref.378ref.ref.ref.
 Quartile 2699–9209662551.03 (0.86–1.23)1.04 (0.86–1.25)1.06 (0.88–1.29)3680.98 (0.85–1.14)1.00 (0.86–1.16)1.01 (0.86–1.18)
 Quartile 3921–1,2009662641.03 (0.85–1.23)1.05 (0.86–1.27)1.08 (0.89–1.32)4001.03 (0.89–1.19)1.05 (0.90–1.23)1.10 (0.93–1.29)
 Quartile 4>1,2009642600.94 (0.78–1.13)0.97 (0.78–1.20)1.01 (0.81–1.26)3790.94 (0.80–1.09)0.96 (0.80–1.15)1.01 (0.84–1.21)
P trend0.410.690.950.480.720.84
 Per 200 mg/day0.99 (0.96–1.02)0.99 (0.95–1.03)1.01 (0.97–1.05)0.99 (0.97–1.02)1.00 (0.97–1.03)1.02 (0.98–1.05)
From dairy
 Quartile 1<327966249ref.ref.ref.387ref.ref.ref.
 Quartile 2327–5249632460.93 (0.78–1.12)0.94 (0.78–1.13)0.94 (0.78–1.13)3610.87 (0.75–1.01)0.88 (0.76–1.02)0.89 (0.76–1.03)
 Quartile 3525–7749642751.06 (0.89–1.27)1.09 (0.90–1.31)1.16 (0.96–1.40)3991.00 (0.86–1.15)1.03 (0.88–1.19)1.10 (0.94–1.28)
 Quartile 4>7749622560.91 (0.76–1.10)0.94 (0.77–1.15)1.02 (0.83–1.25)3760.91 (0.78–1.05)0.94 (0.80–1.10)1.02 (0.87–1.21)
P trend0.530.790.540.490.820.35
 Per 200 mg/day0.99 (0.95–1.02)0.99 (0.95–1.03)1.01 (0.98–1.06)0.99 (0.96–1.02)0.99 (0.96–1.03)1.02 (0.98–1.05)
From nondairy
 Quartile 1<299959277ref.ref.ref.394ref.ref.ref.
 Quartile 2299–3719642600.98 (0.81–1.18)1.01 (0.83–1.22)0.93 (0.77–1.13)3841.03 (0.89–1.20)1.07 (0.91–1.25)0.97 (0.83–1.14)
 Quartile 3372–4709712270.84 (0.69–1.02)0.87 (0.70–1.08)0.84 (0.67–1.05)3540.89 (0.76–1.04)0.92 (0.77–1.10)0.88 (0.74–1.05)
 Quartile 4>4709612620.97 (0.79–1.19)1.03 (0.79–1.34)0.96 (0.74–1.26)3911.04 (0.88–1.23)1.10 (0.88–1.36)1.01 (0.82–1.26)
P trend0.660.920.830.840.540.90
 Per 200 mg/day0.98 (0.89–1.09)1.03 (0.89–1.19)0.98 (0.84–1.14)1.01 (0.93–1.10)1.06 (0.94–1.19)1.01 (0.89–1.14)
  • aStratified by center and adjusted for age at colorectal cancer diagnosis (continuously per one year increase), sex, prediagnostic BMI (continuous), smoking status (never, former, current, unknown), and energy intake (continuous).

  • bAdditionally adjusted for tumor subsite (colon and rectum), disease stage (I, II, III, IV, unknown, unavailable for center), and differentiation grade (well, moderately, poorly, unknown, unavailable for center).