Table 2.

Association between allergic diseases and hematologic malignancies in IWHS subjects (1997–2011)

Age-adjustedMultivariable-adjusted
NPerson-yearsHRa (95% CI)HRb (95% CI)
Myeloid neoplasms
 No allergyc122183,223Ref.Ref.
 Allergyd5580,9611.03 (0.75–1.42)1.00 (0.72–1.37)
 No allergyc122183,223Ref.Ref.
 1 allergyd3344,1521.13 (0.77–1.66)1.08 (0.73–1.60)
 2+ allergiesd822,2200.55 (0.27–1.12)0.53 (0.26–1.08)
 No allergyc122183,223Ref.Ref.
 Asthmae1818,4971.49 (0.91–2.45)1.36 (0.82–2.27)
 Hay fevere1421,0561.00 (0.58–1.75)1.00 (0.58–1.75)
 Skin allergye1431,8920.66 (0.38–1.15)0.65 (0.38–1.14)
 Other allergye2945,2840.97 (0.65–1.45)0.95 (0.63–1.42)
 MDSf
  No allergyc38122,441Ref.Ref.
  Allergyd2153,0591.27 (0.75–2.17)1.20 (0.70–2.03)
  No allergyc38122,441Ref.Ref.
  Asthmae811,8742.17 (1.01–4.64)2.00 (0.93–4.32)
  Hay fevere513,8581.15 (0.45–2.91)1.06 (0.42–2.70)
  Skin allergye520,9310.77 (0.30–1.95)0.73 (0.29–1.85)
  Other allergye1329,7161.30 (0.68–2.48)1.22 (0.64–2.34)
 MPN (includes CML)
  No allergyc46183,373Ref.Ref.
  Allergyd1881,0340.90 (0.52–1.56)0.84 (0.48–1.46)
  No allergyc46183,373Ref.Ref.
  Asthmae418,5190.90 (0.32–2.50)0.67 (0.21–2.15)
  Hay fevere521,0770.97 (0.39–2.44)0.99 (0.39–2.50)
  Skin allergye331,9110.38 (0.12–1.22)0.38 (0.12–1.22)
  Other allergye1145,3271.08 (0.57–2.04)1.05 (0.56–1.00)
Lymphoid neoplasms
 No allergyc306182,300Ref.Ref.
 Allergyd13180,4690.99 (0.81–1.21)0.99 (0.81–1.22)
 No allergyc306182,300Ref.Ref.
 1 allergyd7743,8351.05 (0.82–1.35)1.07 (0.83–1.38)
 2+ allergiesd3322,0710.99 (0.63–1.29)0.99 (0.62–1.29)
 No allergyc306182,300Ref.Ref.
 Asthmae3518,3291.14 (0.80–1.62)1.10 (0.77–1.63)
 Hay fevere2620,9500.75 (0.50–1.12)0.77 (0.51–1.16)
 Skin allergye5031,7190.98 (0.73–1.32)1.03 (0.76–1.38)
 Other allergye6845,0530.91 (0.70–1.18)0.93 (0.72–1.33)
 NHL (includes CLL)
  No allergyc232182,504Ref.Ref.
  Allergyd9580,5580.93 (0.73–1.18)0.95 (0.75–1.22)
  No allergyc232182,504Ref.Ref.
  Asthmae2518,3651.07 (0.71–1.62)1.03 (0.65–1.63)
  Hay fevere2120,9630.78 (0.51–1.25)0.83 (0.52–1.31)
  Skin allergye4031,7321.00 (0.71–1.39)1.05 (0.75–1.47)
  Other allergye4845,1050.85 (0.62–1.15)0.88 (0.64–1.20)
 MM
  No allergyc53183,443Ref.Ref.
  Allergyd2681,0291.17 (0.70–1.79)1.15 (0.72–1.85)
  No allergyc53183,443Ref.Ref.
  Asthmae518,5180.95 (0.38–2.37)0.94 (0.38–2.36)
  Hay fevere321,0860.50 (0.16–1.60)0.51 (0.16–1.62)
  Skin allergye1031,9051.09 (0.56–2.15)1.13 (0.57–2.23)
  Other allergye1445,3341.08 (0.60–1.95)1.11 (0.61–2.01)
  • aAdjusted for age (years, continuous).

  • bAdjusted for age (years, continuous), education (less than high school, high school, more than high school), BMI (kg/m2, categorical; <25, 25–29.9, ≥30 per 1997 follow-up questionnaire), smoking status (yes, no), and residence (rural, urban).

  • cNo allergy reference group includes only individuals indicating no asthma, hay fever, skin allergies, or other allergies.

  • dThe number of cases reporting any allergy is higher than for the sum of those reporting 1 or >2 allergies because individuals with missing responses for specific allergies were excluded from the latter analysis.

  • eColumn may total more than the number of affected cases because some individuals reported more than one allergic condition.

  • fFollow-up time for MDS analysis calculated for the period of 2001 to 2011 because data on MDS were first collected by SEER in 2001. The analysis cohort for MDS (N = 21,293) is smaller than the overall analysis cohort because all cancer cases diagnosed before 2001 were excluded (N = 1,308).