Table 2.

Associations between breast cancer SNPs and percent MD in Norwegian postmenopausal women (N = 2348) and comparisons with published data on the associations of these SNPs with MD and breast cancer risk

Results from the current studyResults from previous studies of genetic variants
MD studyBreast cancer studies
Number of women with
Common homoHeteroRare homo% MD per minor allele% MD per minor allelePer minor allele OR on breast cancer
Gene/regionSNPzygotezygotezygoteBetaaSEPbBetaaSEPcORPReferences
6q25.1rs93839381594237222.050.870.01881.181.41 × 10−7Fletcher et al. (28)
TXNRD2rs81416919251105−1.400.660.03331.120.046Cebrian et al. (58)
2q35rs133870429725915170.550.310.0810−0.04e0.18e0.75c0.831.3 × 1013Stacey et al. (30)
6q25.1rs37348052023285110.890.650.17351.191.35 × 10−7Fletcher et al. (28)
10q26.13rs10510101218636268−0.550.440.20591.121.58 × 106Fletcher et al. (28)
SLC4A7/3p24rs49737685799643650.520.480.27550.48e0.19e0.03c1.114.1 × 10−23Ahmed et al. (22)
9q31.2rs8656868748034690.390.360.27670.92.01 × 10−29Warren et al. (54)
TGFB1rs1800470830829253−0.350.360.33281.150.162Ma et al. (53)
1p11.2rs1124943310618743490.340.380.36100.10e0.22e0.78c1.166.74 × 10−10Thomas et al. (23)
8q24.21rs1328161510618743490.340.380.36100.09e0.21e0.48c1.085 × 10−12Easton et al. (20)
MRPS30:FGF10rs4415084614899356−0.430.470.3647−0.12e0.28e0.99c1.196.4 × 10−10Stacey et al. (21)
COX11/17q23.2rs65049501163826293−0.360.440.41100.21e0.22e0.49c0.951.4 × 10−8Ahmed et al. (22)
CASP8rs1746827714504842680.350.450.4356−0.37e0.36e0.04c0.885.7 × 10−7Cox et al. (24)
MRPS30:FGF10/5p12rs109416791212861172−0.210.320.51400.06e0.23e0.99c1.192.9 × 10−11Stacey et al. (21)
MAP3K1rs8893121070822166−0.230.430.59320.06e0.20e0.57c1.137 × 10−20Easton et al.(20)
LSP1rs38171989779633340.130.410.74490.70e0.21e0.001c,d1.073 × 10−9Easton et al. (20)
TOX3rs38036629797202910.060.360.86690.30e0.22e0.17c1.210−36fEaston et al. (20)

NOTE: Bold indicates P values <0.05. rs17468277 and rs17468277 in strong linkage disequilibrium (LD; r2 = 0.98; Vachon et al; ref. 19).

  • aBeta represents the difference (on an arithmetic scale) in percent density per copy of the minor allele of each SNP after adjustments for age, BMI, and study assuming an additive model of inheritance.

  • bLinear regression adjusted for age, BMI, and study, untransformed.

  • cRoot squared transformed, adjusted for age, BMI, menopausal status, case status, and study (Vachon et al; ref. 19).

  • dPositive association with percent MD.

  • eUntransformed betas and SEs, unpublished data.

  • frs3803662 was not part of the initial tag SNP set but identified as a result of fine-scale mapping and typed in the stage 2 and stage 3 sets (but not the stage 1 set).