Table 2.

Associations between recently identified SNPs and colorectal cancer in the GECCO and CCFR

SNPa,bChromosomal locationGene/locusRiskc alleleBasec alleleORd95% CIPPhetNo. of study sets genotypedNo. of study sets imputedMean RAFMean R2
rs109112511q25.3LAMC1AC1.111.06–1.161.0 × 10−50.560170.570.88
rs66877581q41DUSP10GA1.040.99–1.100.110.091610.201.00
rs66911701q41DUSP10TG1.010.97–1.060.570.253140.370.98
rs119037572q32.3NABP1/SDPRCT1.141.07–1.231.8 × 10−40.320170.170.69
rs109365993q26.2MYNNCT1.020.97–1.070.450.74890.760.98
rs6471615q31.1PITX1/H2AFYAC1.071.02–1.128.5 × 10−30.060170.670.88
rs13213116p21SRSF3/CDKN1AAC1.071.02–1.134.2 × 10−30.277100.250.96
rs7197259p24TPD52L3/IL-33/ UHRF2/GLDCAC1.081.03–1.137.1 × 10−40.280170.621.00
rs166565010q26.2HSPA12ATC0.950.91–1.004.9 × 10−20.200170.270.97
rs382499911q13.4POLD3GT1.101.06–1.157.0 × 10−60.613140.511.00
rs321781012p13.32CCND2TC1.191.10–1.293.1 × 10−50.843140.160.49
rs713670212q13.13LARP4/DIP2BTC1.101.05–1.164.9 × 10−50.453140.320.87
rs1116955212q13.13DIP2B/ATF1CT1.051.00–1.104.0 × 10−20.511610.731.00
rs5933612q24.21TBX3TA1.151.07–1.231.4 × 10−41.5 × 10−30170.480.94
rs242327920p12.3HAO1/PLCB1CT1.071.02–1.127.5 × 10−30.191070.251.00
rs492538620q13.33LAMA5CT1.061.01–1.111.5 × 10−20.451610.691.00
  • aAll SNPs modeled additively, with the exception of rs59336, which was modeled dominantly.

  • bSNPs identified to be associated with colorectal cancer risk in the following studies: rs10911251 [Peters et al. (10)]; rs6687758 [Houlston et al. (4)]; rs6691170 [Houlston et al. (4)]; rs11903757 [Peters et al. (10)]; rs10936599 [Houlston et al. (4)]; rs647161 [Jia et al. (7)]; rs1321311 [Dunlop et al. (3)]; rs719725 [Zanke et al. (14) and Kocarnik et al. (8)]; rs1665650 [Jia et al. (2013)]; rs3824999 [Dunlop et al. (3)]; rs3217810 [Peters et al. (10)]; rs7136702 [Houlston et al. (4)]; rs11169552 [Houlston et al. (4)]; rs59336 [Peters et al. (10)]; rs2423279 [Jia et al. (7)]; rs4925386 [Houlston et al. (4)].

  • cRisk/base allele designation based on the literature.

  • dAdjusted for age, sex, study center, and population substructure (principal components 1–3).