Table 2.

HRs by serum C-reactive protein levels in NHANES III participants

Serum C-reactive protein levels (mg/dL)
Mortality cause≤0.210.22–0.500.51–1.00>1.00PTrend
Colorectal cancer (n)48121715
 Model 1a1 (Ref.)1.94 (1.08–3.50)2.98 (1.33–6.67)3.82 (1.66–8.81)<0.01
 Model 2b1 (Ref.)2.60 (1.38–4.90)3.48 (1.59–7.61)4.24 (1.57–11.46)<0.01
 Model 3c1 (Ref.)2.66 (1.36–5.20)3.40 (1.48–7.77)3.96 (1.64–9.52)<0.01
Other cancers (n)44473145130
 Model 11 (Ref.)0.94 (0.67–1.33)1.24 (0.89–1.73)2.19 (1.61–2.99)<0.01
 Model 21 (Ref.)0.98 (0.67–1.44)1.21 (0.83–1.76)1.85 (1.37–2.49)<0.01
 Model 31 (Ref.)0.96 (0.66–1.39)1.19 (0.83–1.72)1.89 (1.42–2.52)<0.01
CVD (n)1,038226317290
 Model 11 (Ref.)1.23 (1.04–1.45)1.37 (1.11–1.68)2.12 (1.73–2.60)<0.01
 Model 21 (Ref.)1.31 (1.09–1.58)1.39 (1.12–1.73)2.02 (1.56–2.61)<0.01
 Model 31 (Ref.)1.27 (1.04–1.56)1.30 (1.03–1.64)1.87 (1.39–2.51)<0.01
Other causes (n)767149259206
 Model 11 (Ref.)1.10 (0.81–1.48)1.39 (1.12–1.73)2.15 (1.66–2.78)<0.01
 Model 21 (Ref.)1.21 (0.88–1.68)1.24 (1.00–1.53)2.07 (1.59–2.69)<0.01
 Model 31 (Ref.)1.19 (0.86–1.65)1.18 (0.95–1.47)1.95 (1.51–2.51)<0.01

NOTE: Data are given as HR (95% CIs).

Abbreviations: CVD, cardiovascular disease; n, number of events; ref., reference group.

  • aModel 1: Adjusted for age.

  • bModel 2: Adjusted for age, gender, race–ethnicity, level of education, annual family income, BMI, pack-years of smoking, serum cotinine levels, alcohol consumption, and physical activity.

  • cModel 3: Adjusted for variables in model 2 and hypertension status, diabetes status, hypercholesterolemia, supplement use, nonsteroidal anti-inflammatory drug use, and hormone use in women.