Table 1.

Comparison of performance of BRCAPRO version 2.0-7 and version 2.0-8 with 95% BCa marginal CIs

OverallCBC in familyCBC proband
AUC 2.0-70.7884 (0.7613, 0.8126)0.7785 (0.7177, 0.8295)0.7479 (0.6533, 0.8220)
AUC 2.0-80.7927 (0.7661, 0.8169)0.7788 (0.7185, 0.8311)0.7547 (0.6623, 0.8274)
Embedded Image0.0043 (0.0005, 0.0082)0.0002 (−0.0189, 0.0194)0.0068 (−0.0016, 0.0312)
OE 2.0-70.8910 (0.8239, 0.9608)0.5515 (0.4700, 0.6360)0.5837 (0.4680, 0.7051)
OE 2.0-80.9765 (0.9036, 1.0519)0.7296 (0.6198, 0.8402)0.8018 (0.6445, 0.9750)
Embedded Image0.0855 (0.0722, 0.1021)0.1781 (0.1441, 0.2186)0.2181 (0.1634, 0.2894)
RMSE 2.0-70.3854 (0.3698, 0.4020)0.4998 (0.4652, 0.5355)0.5314 (0.4789, 0.5848)
RMSE 2.0-80.3745 (0.3587, 0.3910)0.4448 (0.4090, 0.4805)0.4682 (0.4162, 0.5240)
Embedded Image−0.0108 (−0.0154, −0.0067)−0.0551 (−0.0761, −0.0347)−0.0633 (−0.0984, −0.0306)

NOTE: Rows labeled by Δ contain the difference of the figure of merit between BRCAPRO 2.0-7 and 2.0-8, with corresponding 95% CIs. The differences ΔOE and ΔRMSE are statistically significant.