Table 4.

Association of serum vitamin D concentration with prostate cancer risk: SELECT African Americans only

Model	Vitamin D (nmol/L)	N (case)	N (cohort)	HR	95% CI	P
Overall prostate cancer
Model 1^a	<37.5	90	276	1.00
	37.5–<50	70	180	1.24	0.81–1.88	0.319
	50–<75	58	218	0.85	0.56–1.28	0.437
	≥75	32	128	0.84	0.50–1.40	0.509
Model 2^a,^b	<37.5	92	274	1.00
	37.5–<50	66	180	1.16	0.76–1.77	0.498
	50–<75	61	228	0.81	0.54–1.22	0.317
	≥75	31	120	0.86	0.51–1.44	0.555
Model 3^a,^b,^c	<30.1	51	161	1.00
	30.1–<40.4	58	159	1.27	0.79–2.05	0.330
	40.4–<52.9	61	161	1.33	0.81–2.18	0.256
	52.9–<69.1	40	160	0.76	0.45–1.29	0.316
	≥69.1	40	161	0.89	0.53–1.49	0.658
Model 4^a,^b,^d	<44.1	126	362	1.00
	44.1–<58.2	55	183	0.90	0.59–1.38	0.636
	58.2–<72.9	33	112	0.83	0.51–1.34	0.440
	72.9–<90.7	16	77	0.69	0.37–1.28	0.242
	≥90.7	20	68	0.84	0.47–1.53	0.574
Gleason 2–6 prostate cancer
Model 1^a	<37.5	46	276	1.00
	37.5–<50	37	180	1.27	0.74–2.17	0.387
	50–<75	32	218	0.95	0.55–1.63	0.839
	≥75	17	128	0.96	0.48–1.92	0.900
Model 2^a,^b	<37.5	45	274	1.00
	37.5–<50	32	180	1.11	0.64–1.93	0.717
	50–<75	38	228	1.07	0.64–1.78	0.800
	≥75	17	120	1.04	0.52–2.10	0.910
Model 3^a,^b,^c	<30.0	24	161	1.00
	30.0–<40.4	30	159	1.45	0.77–2.76	0.252
	40.4–<52.9	33	161	1.57	0.82–3.01	0.170
	52.9–<69.1	24	160	1.01	0.51–2.01	0.971
	≥69.1	21	161	1.10	0.54–2.22	0.800
Model 4^a,^b,^d	<44.1	60	362	1.00
	44.1–<58.2	33	183	1.11	0.64–1.94	0.712
	58.2–<72.9	20	112	1.11	0.61–2.03	0.730
	72.9–<90.7	7	77	0.71	0.29–1.77	0.467
	≥90.7	12	68	1.14	0.53–2.48	0.733
Gleason 7–10 prostate cancer
Model 1^a	<37.5	29	276	1.00
	37.5–<50	23	180	1.18	0.62–2.25	0.617
	50–<75	19	218	0.90	0.47–1.70	0.737
	≥75	7	128	0.52	0.22–1.24	0.142
Model 2^a,^b,^e	<37.5	31	274	1.00
	37.5–<50	25	180	1.39	0.73–2.63	0.316
	50–<75	16	227	0.65	0.33–1.27	0.206
	≥75	6	120	0.47	0.19–1.18	0.106
Model 3^a,^b,^c	<30.0	17	161	1.00
	30.0–<40.4	19	159	1.31	0.62–2.75	0.480
	40.4–<52.9	21	161	1.49	0.69–3.23	0.313
	52.9–<69.0	10	160	0.64	0.27–1.53	0.313
	≥69.0	11	161	0.76	0.33–1.76	0.516
Model 4^a,^b,^d,^f	<44.1	45	362	1.00
	44.1–<58.2	16	183	0.89	0.46–1.72	0.729
	58.2–<72.9	8	112	0.54	0.24–1.21	0.133
	72.9–<90.7	4	77	0.46	0.16–1.34	0.154
	≥90.7	5	68	0.58	0.22–1.53	0.142

↵^aHRs adjusted for age (through matching) and family history of prostate cancer, BMI, baseline diabetes, and SELECT treatment arm (as covariates).
↵^bVitamin D values adjusted for month of serum sample.
↵^cQuintiles are calculated based on the distribution among African American cohort.
↵^dQuintiles are calculated based on the distribution among the entire cohort.
↵^eP_trend = 0.048.
↵^fP_trend = 0.056.