Table 4.

Association of serum vitamin D concentration with prostate cancer risk: SELECT African Americans only

ModelVitamin D (nmol/L)N (case)N (cohort)HR95% CIP
Overall prostate cancer
 Model 1a<37.5902761.00
37.5–<50701801.240.81–1.880.319
50–<75582180.850.56–1.280.437
≥75321280.840.50–1.400.509
 Model 2a,b<37.5922741.00
37.5–<50661801.160.76–1.770.498
50–<75612280.810.54–1.220.317
≥75311200.860.51–1.440.555
 Model 3a,b,c<30.1511611.00
30.1–<40.4581591.270.79–2.050.330
40.4–<52.9611611.330.81–2.180.256
52.9–<69.1401600.760.45–1.290.316
≥69.1401610.890.53–1.490.658
 Model 4a,b,d<44.11263621.00
44.1–<58.2551830.900.59–1.380.636
58.2–<72.9331120.830.51–1.340.440
72.9–<90.716770.690.37–1.280.242
≥90.720680.840.47–1.530.574
Gleason 2–6 prostate cancer
 Model 1a<37.5462761.00
37.5–<50371801.270.74–2.170.387
50–<75322180.950.55–1.630.839
≥75171280.960.48–1.920.900
 Model 2a,b<37.5452741.00
37.5–<50321801.110.64–1.930.717
50–<75382281.070.64–1.780.800
≥75171201.040.52–2.100.910
 Model 3a,b,c<30.0241611.00
30.0–<40.4301591.450.77–2.760.252
40.4–<52.9331611.570.82–3.010.170
52.9–<69.1241601.010.51–2.010.971
≥69.1211611.100.54–2.220.800
 Model 4a,b,d<44.1603621.00
44.1–<58.2331831.110.64–1.940.712
58.2–<72.9201121.110.61–2.030.730
72.9–<90.77770.710.29–1.770.467
≥90.712681.140.53–2.480.733
Gleason 7–10 prostate cancer
 Model 1a<37.5292761.00
37.5–<50231801.180.62–2.250.617
50–<75192180.900.47–1.700.737
≥7571280.520.22–1.240.142
 Model 2a,b,e<37.5312741.00
37.5–<50251801.390.73–2.630.316
50–<75162270.650.33–1.270.206
≥7561200.470.19–1.180.106
 Model 3a,b,c<30.0171611.00
30.0–<40.4191591.310.62–2.750.480
40.4–<52.9211611.490.69–3.230.313
52.9–<69.0101600.640.27–1.530.313
≥69.0111610.760.33–1.760.516
 Model 4a,b,d,f<44.1453621.00
44.1–<58.2161830.890.46–1.720.729
58.2–<72.981120.540.24–1.210.133
72.9–<90.74770.460.16–1.340.154
≥90.75680.580.22–1.530.142
  • aHRs adjusted for age (through matching) and family history of prostate cancer, BMI, baseline diabetes, and SELECT treatment arm (as covariates).

  • bVitamin D values adjusted for month of serum sample.

  • cQuintiles are calculated based on the distribution among African American cohort.

  • dQuintiles are calculated based on the distribution among the entire cohort.

  • ePtrend = 0.048.

  • fPtrend = 0.056.